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1 Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
* To whom correspondence should be addressed. E-mail: jureta.horton{at}utsouthwestern.edu.
Gender-related differences in immune responses to hemorrhage and sepsis have been described. However, most trauma studies continue to limit experimental models to
males in order to avoid the variable responses associated with hormonal fluctuation in proestrus/estrus females. In this present study, male and female (either diestrus or
proestrus/estrus) Sprague Dawley rats (250-325g) were given a 3° scald burn over 40% TBSA and fluid resuscitated (lactated Ringer=s, 4 ml/kg/% burn); sham burn males and
diestrus as well as sham burn proestrus/estrus female rats were included to provide controls. Twenty-four hours postburn, hearts were either perfused to examine mechanical
function (Langendorff, N=8-9 hearts/group) or to prepare cardiomyocytes (collagenase digestion, N=4-5 hearts/group). Left-ventricular developed pressure and ±dP/dt responses to increases in preload were significantly lower in burned males compared to responses measured in either burned proestrus/estrus or burned diestrus females; burn traumaincreased cardiomyocyte secretion of TNF-
, IL-1
, and NO to a lesser extent in proestrus/estrus females than levels secreted by either diestrus females or males. Similarly, myocytes from proestrus/estrus females accumulated significantly less sodium/calcium compared to values measured in males (p<0.05). Our data confirm gender-related differences in myocardial function and myocardial inflammatory responses to burn injury.
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