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Am J Physiol Heart Circ Physiol (February 21, 2003). doi:10.1152/ajpheart.00721.2002
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Submitted on August 21, 2002
Accepted on February 6, 2003

Tissue Window Chamber System for Validation of Implanted Oxygen Sensors

Milan T. Makale1, Joe T. Lin1, Richard E. Calou1, Amy G. Tsai1, Peter C. Chen1, and David A. Gough1*

1 Department of Bioengineering, University of California San Diego, La Jolla, CA, USA

* To whom correspondence should be addressed. E-mail: dgough{at}bioeng.ucsd.edu.

An experimental system is described for validating electrochemical oxygen sensors implanted in tissues. The system is a modified hamster window chamber in which a thin layer of vascularized tissue is held between two plates, one having an observation window and the other an array of oxygen sensors. This arrangement permits simultaneous recording of oxygen sensor signals and non-destructive visualization of the tissue adjacent to the sensors over periods of one month or more, without the inhibitory effects of anesthesia. The system provides a means for study of the effects of spatial and temporal oxygen distributions on the sensor signals and adaptation of the tissue structure over time. Examples are given of sensor recordings and images of tissues with implanted oxygen sensor arrays.




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 Am. J. Physiol. Heart Circ. Physiol.Home page
M. T. Makale, P. C. Chen, and D. A. Gough
Variants of the tissue-sensor array window chamber
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H57 - H65.
[Abstract] [Full Text] [PDF]


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