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Articles in PresS, published online ahead of print January 24, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00731.2001
Submitted on August 14, 2001
Accepted on January 21, 2002
1 Department of Mathematical Physics and Astronomy, Gent University, Gent, Belgium
2 Academic Medical Center, Department of Physiology, University of Amsterdam, Amsterdam, Netherlands; Department of Medical Physiology, University Medical Center Utrecht, Utrecht, Netherlands
3 Institute for Theoretical Biology, Humboldt University, Berlin, Germany
4 Department of Theoretical Biology, Utrecht University, Utrecht, Netherlands
Recent experimental and theoretical results have stressed the importance of modeling studies of reentrant arrhythmias in cardiac tissue and at the whole heart level. We introduce a six-variable model obtained by a reformulation of the Priebe-Beuckelmann model of a single human ventricular cell. The reformulated model is 3.8 times faster for numerical computations and it is more stable than the original model. It retains the action potential shape at various frequencies, restitution of action potential duration, and restitution of conduction velocity. We were able to reproduce the main properties of epicardial, endocardial and M-cells by modifying selected ionic currents. We perform a simulation study of spiral wave behavior in a 2D sheet of human ventricular tissue and show that spiral waves have a frequency of 3.3 Hz and a linear core of about ~50 mm diameter that rotates with an average frequency of 0.62 rad/s. Simulation results agree with experimental data. In conclusion, the proposed model is suitable for efficient and accurate studies of reentrant phenomena in human ventricular tissue.
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