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Articles in PresS, published online ahead of print December 20, 2001
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00733.2001
Submitted on August 15, 2001
Accepted on December 31, 1969
1 Physiology, Wayne State University School of Medicine, Detroit, MI, USA
* To whom correspondence should be addressed. E-mail: sdicarlo{at}med.wayne.edu.
Individuals with spinal cord injuries above thoracic level 6 (T6) experience life threatening bouts of hypertension termed autonomic dysreflexia (AD). AD is mediated by peripheral 
-adrenergic receptor supersensitivity as well as a reorganization of spinal pathways controlling sympathetic preganglionic neurons. A single bout of dynamic exercise may be a safe therapeutic approach to reduce the severity of AD since mild to moderate dynamic exercise reduces post-exercise -adrenergic receptor responsiveness, lowers post-exercise sympathetic nerve activity and reduces the post-exercise response to stress. Therefore, this study was designed to test the hypothesis that mild to moderate dynamic exercise attenuates the post-exercise response to colon distension (mechanism to elicit AD). To test this hypothesis, six male Wistar rats (406 ± 23 grams), 5 weeks post T 5 spinal cord transection, were instrumented with an arterial catheter. After recovery, the response to graded colon distension (10, 30, 50, 80 mmHg, in random order) was determined before and after a single bout of mild to moderate dynamic exercise (9-12m/min, 0% grade for 40 minutes). After exercise the pressor response to graded colon distension was significantly attenuated (pre-exercise 
2 ± 1, 9 ± 1, 14 ± 1, and 24 ± 2 versus post-exercise 2 ± 1, 2 ± 1, 9 ± 1 and 12 ± 3 mmHg). Thus, acute exercise is a safe, therapeutic approach to reduce the severity of AD in paraplegic subjects.
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