| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Molecular and Cellular Biology, Sunnybrook and Women's Research Institute, Toronto, Canada
2 Cardiology, St. Michael's Hospital , Rm:8009, Queen's Wing, Toronto, M5B 1W8, Canada
3 Cardiology Division, St. Michael's Hospital, Toronto, Canada
* To whom correspondence should be addressed. E-mail: dan.dumont{at}swri.ca.
Angiopoietin-2 has been implicated in the angiogenic response, however this response has been tied to the expression of VEGF and an independent angiogenic role has yet to be described. In this report, we detail the generation of transgenic mice that conditionally express Angiopoietin-2 in the liver, resulting in sustained increases in circulating levels. These animals survive gestation and present with several vascular abnormalities including increase in the diameter of myocardial coronary vessels and a reduction in the density of endocardial vessels. In the lung, prominent increases in vessel diameter, as well as vascular leakage, airway remodeling and mucus metaplasia were observed. These vascular remodeling changes occurred in the absence of any apparent increase in VEGF expression. Our results illustrate that chronic systemic delivery of Angiopoietin-2 induces angiogenesis in the absence of increased VEGF expression and that Angiopoietin-2 promotes myocardial coronary vessel remodeling and may play a role in airway remodeling.
This article has been cited by other articles:
|
|
 |
|
  J.-X. Chen and A. Stinnett Disruption of Ang-1/Tie-2 Signaling Contributes to the Impaired Myocardial Vascular Maturation and Angiogenesis in Type II Diabetic Mice Arterioscler. Thromb. Vasc. Biol., September 1, 2008; 28(9): 1606 - 1613. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q.-h. Tuo, H. Zeng, A. Stinnett, H. Yu, J. L. Aschner, D.-F. Liao, and J.-X. Chen Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2547 - H2557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Tressel, R.-P. Huang, N. Tomsen, and H. Jo Laminar Shear Inhibits Tubule Formation and Migration of Endothelial Cells by an Angiopoietin-2-Dependent Mechanism Arterioscler. Thromb. Vasc. Biol., October 1, 2007; 27(10): 2150 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Davis, A. Dei Cas, D. A. Long, K. E. White, A. Hayward, C.-H. Ku, A. S. Woolf, R. Bilous, G. Viberti, and L. Gnudi Podocyte-Specific Expression of Angiopoietin-2 Causes Proteinuria and Apoptosis of Glomerular Endothelia J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2320 - 2329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Reiss, J. Droste, M. Heil, S. Tribulova, M. H.H. Schmidt, W. Schaper, D. J. Dumont, and K. H. Plate Angiopoietin-2 Impairs Revascularization After Limb Ischemia Circ. Res., July 6, 2007; 101(1): 88 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F.-C. Ye, D. J. Blackbourn, M. Mengel, J.-P. Xie, L.-W. Qian, W. Greene, I-T. Yeh, D. Graham, and S.-J. Gao Kaposi's Sarcoma-Associated Herpesvirus Promotes Angiogenesis by Inducing Angiopoietin-2 Expression via AP-1 and Ets1 J. Virol., April 15, 2007; 81(8): 3980 - 3991. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
