| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 U684, INSERM, Nancy, France; UFR Medecine, Universite Henri Poincare, Nancy, France
2 UFES, CIC, Vitoria, Brazil
3 FRE 2867, CNRS, Paris, France; UFR923, Universite Pierre et Marie Curie, Paris, France
4 Diagnosis Center, Hopital Hotel-Dieu, Paris, France; UFR Medecine, Universite Paris V, Paris, France
* To whom correspondence should be addressed. E-mail: michel.safar{at}htd.ap-hop-paris.fr.
In spontaneously hypertensive rats (SHR), carotid and aortic distensibility measured at operational blood pressure (BP) is reduced. Increased body weight and mean arterial pressure (MAP) are known both to reduce independently distensibility. However, whether, after adjustment to body weight and mean BP, distensibility remains reduced in SHR has never been investigated. Carotid and abdominal aorta distensibility was measured under anesthesia in SHR at 5, 12, 52 and 78 weeks of age and compared with age-matched normotensive Wistar rats. Each age group was composed of 9-10 animals. Distensibility was determined using echo-tracking techniques of high resolution. By comparison with Wistar rats, carotid and aortic distensibility measured at operational MAP is reduced in SHR. This reduction is accentuated with age, particularly for the carotid artery. After adjustment to body weight and MAP, carotid and aortic distensibility becomes identical in Wistar and SHR (or even slightly increased in SHR) but continues to be reduced with age, mainly for the carotid artery. In conclusion, in SHR, age and high BP have not a parallel and similar influence on the reduction of arterial distensibility. Whereas aging constantly reduces arterial distensibility, the MAP level rather contributes to maintain arterial function.
This article has been cited by other articles:
|
|
 |
|
  H. Macarthur, T. C. Westfall, and G. H. Wilken Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H183 - H189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Burattini and P. O. Di Salvia Development of systemic arterial mechanical properties from infancy to adulthood interpreted by four-element windkessel models J Appl Physiol, July 1, 2007; 103(1): 66 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cosson, M. Herisse, D. Laude, F. Thomas, P. Valensi, J.-R. Attali, M. E. Safar, and H. Dabire Aortic stiffness and pulse pressure amplification in Wistar-Kyoto and spontaneously hypertensive rats Am J Physiol Heart Circ Physiol, May 1, 2007; 292(5): H2506 - H2512. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
