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Am J Physiol Heart Circ Physiol (November 15, 2001). doi:10.1152/ajpheart.00750.2001
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Articles in PresS, published online ahead of print November 14, 2001
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00750.2001
Submitted on August 21, 2001
Accepted on November 12, 2001

High-cut characteristics of the baroreflex neural arc preserve baroreflex gain against pulsatile pressure

Toru Kawada1*, Can Zheng1, Yusuke Yanagiya1, Kazunori Uemura1, Tadayoshi Miyamoto1, Masashi Inagaki1, Toshiaki Shishido1, Masaru Sugimachi1, and Kenji Sunagawa1

1 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka, Japan

* To whom correspondence should be addressed. E-mail: torukawa{at}res.ncvc.go.jp.

A transfer function from baroreceptor pressure input to sympathetic nerve activity (SNA) shows derivative characteristics in the frequency range below 0.8 Hz in rabbits. These derivative characteristics contribute to a quick and stable arterial pressure (AP) regulation. However, if the derivative characteristics hold up to heart rate frequency, the pulsatile pressure input will yield a markedly augmented SNA signal. Such a signal would saturate the baroreflex signal transduction, thereby disabling the baroreflex regulation of AP. We hypothesized that the transfer gain at heart rate frequency would be much smaller than that predicted from extrapolating the derivative characteristics. In anesthetized rabbits (n=6), we estimated the neural arc transfer function in the frequency range up to 10 Hz. The transfer gain was lost at a rate of -20 dB/decade when the input frequency exceeded 0.8 Hz. A numerical simulation indicated that the high-cut characteristics above 0.8 Hz were effective to attenuate the pulsatile signal and preserve the open-loop gain when the baroreflex dynamic range was finite.




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