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Am J Physiol Heart Circ Physiol (March 11, 2004). doi:10.1152/ajpheart.00752.2003
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Submitted on August 7, 2003
Accepted on March 6, 2004

Cardiac sympathetic nerve stimulation does not attenuate dynamic vagal control of heart rate via the {alpha}-adrenergic mechanism

Tadayoshi Miyamoto1*, Toru Kawada2, Yusuke Yanagiya3, Masashi Inagaki2, Hiroshi Takaki2, Masaru Sugimachi2, and Kenji Sunagawa2

1 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka, Japan; Japan Association for the Advancement of Medical Equipm, Tokyo, Japan
2 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
3 Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, Suita, Osaka, Japan; The Organization for Pharmaceutical Safety and Research, Tokyo, Japan

* To whom correspondence should be addressed. E-mail: miyamoto{at}res.ncvc.go.jp.

Complex sympatho-vagal interactions govern heart rate (HR). Activation of the postjunctional {beta}-adrenergic receptors on the sinus nodal cells augments the HR response to vagal stimulation, whereas exogenous activation of the presynaptic {alpha}-adrenergic receptors on the vagal nerve terminals attenuates vagal control of HR. Whether the {alpha}-adrenergic mechanism associated with cardiac postganglionic sympathetic nerve activation plays a significant role in modulation of the dynamic vagal control of HR remains unknown. The right vagal nerve was stimulated in seven anesthetized rabbits which had undergone sinoaortic denervation and vagotomy according to a binary white noise signal (0-10 Hz) for 10 min; subsequently, the transfer function from vagal stimulation to HR was estimated. The effects of {beta}-adrenergic blockade with intravenous propranolol (1 mg/kg iv) and the combined effects of {beta}-adrenergic blockade and tonic cardiac sympathetic nerve stimulation at 5 Hz were examined. The transfer function from vagal stimulation to HR approximated a first-order low-pass filter with pure delay. {beta}-adrenergic blockade decreased the dynamic gain from 6.0 ± 0.4 to 3.7 ± 0.6 beats.min-1.Hz-1 (P<0.01) with no alteration of the corner frequency or pure delay. Under {beta}-adrenergic blockade conditions, tonic sympathetic stimulation did not change further the dynamic gain (3.8 ± 0.5 beats.min-1.Hz-1). In conclusion, cardiac postganglionic sympathetic nerve stimulation did not affect the dynamic HR response to vagal stimulation via the {alpha}-adrenergic mechanism.




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