| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
2 Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan; Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan
3 Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan; Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Japan
4 Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan
* To whom correspondence should be addressed. E-mail: t-miyauc{at}md.tsukuba.ac.jp.
Exercise training improves the aging-induced downregulation of myosin heavy chain (MHC) and sarcoplasmic reticulum Ca2+-ATPase (SR-Ca2+-ATPase), which participate in the regulation of cardiac contraction and relaxation. Thyroid hormone receptor (TR), a transcriptional activator, affected a regulation of gene expression of MHC and SR-Ca2+-ATPase. We hypothesized that myocardial TR signaling contributes to a molecular mechanism of exercise training-induced improvement of MHC and SR-Ca2+-ATPase genes
with cardiac function in old age. We investigated whether TR signaling and gene expression of MHC and SR-Ca2+-ATPase in the aged heart are affected by exercise training, using the hearts of sedentary young rats (4 months old), sedentary aged rats (23 months old), and trained aged rats (23 months old, swimming training for 8 weeks). Trained-aged rats showed improvement in cardiac function. Expression of TR-
1 and TR-
1 proteins in the heart were significantly lower in sedentary-aged rats than in sedentary-young rats, and were significantly higher in trained-aged rats than in sedentary-aged rats. The activity of TR DNA binding to the transcriptional regulatory region in the -MHC and SR-Ca2+-ATPase genes and the mRNA and protein expression of -MHC and SR-Ca2+-ATPase in the heart and plasma T3 and T4 levels were altered in association with changes in the myocardial TR protein levels. These findings suggest that exercise training improves the aging-induced downregulation of myocardial TR signaling-mediated transcription of MHC and SR-Ca2+- ATPase genes, thereby contributing to the improvement of cardiac function in trained-aged hearts.
This article has been cited by other articles:
|
|
 |
|
  T. Bupha-Intr, J. Laosiripisan, and J. Wattanapermpool Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats J Appl Physiol, October 1, 2009; 107(4): 1105 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Jiao, Y. Bai, T. Akaike, H. Takeshima, Y. Ishikawa, and S. Minamisawa Sarcalumenin is essential for maintaining cardiac function during endurance exercise training Am J Physiol Heart Circ Physiol, August 1, 2009; 297(2): H576 - H582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Groban, H. Jobe, M. Lin, T. Houle, D. A. Kitzman, and W. Sonntag Effects of Short-Term Treadmill Exercise Training or Growth Hormone Supplementation on Diastolic Function and Exercise Tolerance in Old Rats J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2008; 63(9): 911 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iemitsu, N. Shimojo, S. Maeda, Y. Irukayama-Tomobe, S. Sakai, T. Ohkubo, Y. Tanaka, and T. Miyauchi The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H136 - H144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Hydock, C.-Y. Lien, C. M. Schneider, and R. Hayward Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3254 - H3264. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Schultz, J. G. Swallow, R. P. Waters, J. A. Kuzman, R. A. Redetzke, S. Said, G. M. de Escobar, and A. M. Gerdes Effects of Excessive Long-Term Exercise on Cardiac Function and Myocyte Remodeling in Hypertensive Heart Failure Rats Hypertension, August 1, 2007; 50(2): 410 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. E. Buroker, M. E. Young, C. Wei, K. Serikawa, M. Ge, X.-H. Ning, and M. A. Portman The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart Am J Physiol Endocrinol Metab, February 1, 2007; 292(2): E453 - E460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Iemitsu, S. Maeda, S. Jesmin, T. Otsuki, Y. Kasuya, and T. Miyauchi Activation pattern of MAPK signaling in the hearts of trained and untrained rats following a single bout of exercise J Appl Physiol, July 1, 2006; 101(1): 151 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Starnes, A. M. Choilawala, R. P. Taylor, M. J. Nelson, and M. D. Delp Myocardial Heat Shock Protein 70 Expression in Young and Old Rats After Identical Exercise Programs J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2005; 60(8): 963 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Thomas, J. A. Kuzman, B. E. Anderson, S. M. K. Andersen, E. H. Schlenker, M. S. Holder, and A. M. Gerdes Thyroid hormones induce unique and potentially beneficial changes in cardiac myocyte shape in hypertensive rats near heart failure Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2118 - H2122. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
