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Articles in PresS, published online ahead of print November 23, 2001
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00764.2001
Submitted on August 27, 2001
Accepted on November 15, 2001
1 Hydraulics Laboratory - Institute of Biomedical Technology, Ghent University, Gent, Belgium
2 Biomedical Engineering Laboratory, EPFL, Lausanne, Switzerland
3 Laboratory for Physiology - Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, Netherlands
* To whom correspondence should be addressed. E-mail: patrick.segers{at}navier.rug.ac.be.
Effective arterial elastance (Ea), defined as the ratio of left ventricular (LV) end-systolic pressure and stroke volume, lumps the steady and pulsatile components of the arterial load in a concise way. Combined with Emax, the slope of the LV end-systolic pressure-volume relation, Ea/Emax has been used to assess heart-arterial coupling. A mathematical heart-arterial interaction model was used to study the effects of changes in peripheral resistance (R, 0.6-1.8 mmHg/(ml/s)) and total arterial compliance (C, 0.5-2.0 ml/mmHg) covering the human patho-physiological range. Ea, Ea/Emax, LV stroke work and hydraulic power were calculated for all conditions. Multiple linear regression analysis revealed a linear relation between Ea, R/T and 1/C: Ea = -0.13 + 1.02 R/T + 0.31/C (with T cycle length) indicating that R/T contributes about 3 times more to Ea than arterial stiffness (1/C). It is demonstrated that different patho-physiological combinations of R and C may lead to the same Ea and Ea/Emax, but can result in differences of 10% in stroke work and 50% in maximal power.
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