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Articles in PresS, published online ahead of print February 21, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00766.2001
Submitted on August 27, 2001
Accepted on February 19, 2002
1 Surgery, Indiana University School of Medicine, Indianapolis, IN, USA
2 Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA
3 Experimental Pathology, Methodist Research Institute/Clarion Health Partners, Indianapolis, IN, USA
4 Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA
* To whom correspondence should be addressed. E-mail: junthank{at}iupui.edu.
The effect of maturation on collateral development of resistance arteries was investigated. 3-4 sequential mesenteric arteries were ligated to create collateral pathways in anesthetized young (~200g) and mature (~600g) rats. Blood flow was similarly elevated in collaterals of young and mature animals. In vivo inner arterial diameter was increased only within young collaterals (33±7%, p<0.001). Increases in number of intimal nuclei (57±10 vs. 52±14%) and cross-sectional medial area (33±13% vs. 38±5%) were similar between young and mature collaterals. Relative to same animal controls, collateral eNOS mRNA was increased as much in mature as young rats. Proteomic analysis revealed significant differences in protein expression with maturation between control arteries as well as flow-loaded collateral vessels. The results indicate that, while intimal and medial remodeling events were similar in collaterals of young and mature rats, luminal expansion occurred only in the young. Alteration in arterial protein expression with maturation and altered responses to stimuli for collateral development may contribute to this impairment.
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