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Am J Physiol Heart Circ Physiol (October 12, 2007). doi:10.1152/ajpheart.00772.2007
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Submitted on July 4, 2007
Accepted on October 5, 2007

Interaction of Angiogenic Microvessels with the Extracellular Matrix

Laxminarayanan Krishnan1, James B Hoying2, Quynhhoa T Nguyen3, Helen Song2, and Jeffrey A. Weiss4*

1 Bioengineering, University of Utah, Salt Lake City, Utah, United States
2 Biomedical Engineering, University of Arizona, Tucson, Arizona, United States
3 Bioengineering, University of Utah, salt lake city, Utah, United States
4 Bioengineering, University of Utah, 50 S. Central Campus Drive, Rm. 2480, Salt Lake City, Utah, 84112, United States

* To whom correspondence should be addressed. E-mail: jeff.weiss{at}utah.edu.

The extracellular matrix (ECM) plays a critical role in angiogenesis by providing biochemical and positional cues as well as mechanically influencing microvessel cell behavior. Considerable information is known concerning the biochemical cues relevant to angiogenesis, but less is known about the mechanical dynamics during active angiogenesis. The objective of this study was to characterize changes in the material properties of a simple angiogenic tissue before and during angiogenesis. During sprouting, there was an overall decrease in tissue stiffness followed by an increase during neovessel elongation. The fall in matrix stiffness coincided with peak MMP mRNA expression and elevated proteolytic activity. An elevated expression of genes for ECM componenets and cell-ECM interaction molecules and a subsequent drop in proteolytic activity (although enzyme levels remained elevated) coincided with the subsequent stiffening.. The results of this study show that the mechanical properties of a scaffold tissue may be actively modified during angiogenesis by the growing microvasculature.




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