AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (February 27, 2003). doi:10.1152/ajpheart.00785.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/6/H2375    most recent
00785.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peralta, J. G
Right arrow Articles by Poderoso, J. J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peralta, J. G
Right arrow Articles by Poderoso, J. J
Submitted on September 5, 2002
Accepted on February 16, 2003

The modulation of mitochondrial nitric oxide synthase and energy expenditure in rat cold acclimation

Jorge G Peralta1, Paola V Finocchietto1, Daniela Converso1, Francisco Schopfer1, Maria C Carreras1, and Juan J Poderoso1*

1 Laboratory of Oxygen Metabolism, University of Buenos Aires, Buenos Aires, Capital, Argentina

* To whom correspondence should be addressed. E-mail: jpoderos{at}fmed.uba.ar.

To preserve thermoneutrality, cold exposure is followed by changes in energy expenditure and basal metabolic rate (BMR). Since nitric oxide (NO) modulates mitochondrial O2 uptake and energy levels, we analyzed cold effects (30 days at 4°C) on rat liver and skeletal muscle mitochondrial nitric oxide synthases (mtNOS) and their putative impact on BMR. Cold exposure delimited two periods: A (days 1-10) with high systemic O2 uptake and weight loss and B, (days 10-30) with lowering of O2 uptake and fat deposition. mtNOS activity and expression decreased in period A and thereafter increased in period B by 60-100% in liver and skeletal muscle (p<0.05). Conversely, mitochondrial O2 uptake remained initially high in the presence of l-arginine while further, it resulted inhibited by 30-50% (p<0.05). On this basis, estimated fractional contribution of liver plus muscle to total BMR varied from 40 % in A, to 25% in B. The transitional modulation of mtNOS in rat cold acclimation could participate in adaptive responses either favoring calorigenesis or conservative energy-saving mechanisms.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. Zaobornyj, L. B. Valdez, P. La Padula, L. E. Costa, and A. Boveris
Effect of sustained hypobaric hypoxia during maturation and aging on rat myocardium. II. mtNOS activity
J Appl Physiol, June 1, 2005; 98(6): 2370 - 2375.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. F. Gonzales, F. A. Chung, S. Miranda, L. B. Valdez, T. Zaobornyj, J. Bustamante, and A. Boveris
Heart mitochondrial nitric oxide synthase is upregulated in male rats exposed to high altitude (4,340 m)
Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2568 - H2573.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Galli, M. I. Labato, E. Bal de Kier Joffe, M. C. Carreras, and J. J. Poderoso
Decreased Mitochondrial Nitric Oxide Synthase Activity and Hydrogen Peroxide Relate Persistent Tumoral Proliferation to Embryonic Behavior
Cancer Res., October 1, 2003; 63(19): 6370 - 6377.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.