AJP - Heart Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (March 27, 2003). doi:10.1152/ajpheart.00793.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/2/H784    most recent
00793.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wei, C.-C.
Right arrow Articles by Dell'Italia, L. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wei, C.-C.
Right arrow Articles by Dell'Italia, L. J.
Submitted on September 7, 2001
Accepted on March 20, 2003

CARDIAC INTERSTITIAL BRADYKININ AND MAST CELLS MODULATE THE PATTERN OF LEFT VENTRICULAR REMODELING IN VOLUME OVERLOAD IN THE RAT

Chih-Chang Wei1, Pamela A. Lucchesi2, Jose Tallaj1, Wayne E. Bradley2, Pamela Powell2, and Louis J. Dell'Italia1*

1 Department of Medicine/Cardiovascular Medicine, Birmingham VA Medical Center, Birmingham, AL, USA; Department of Medicine and Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA
2 Department of Medicine and Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA

* To whom correspondence should be addressed. E-mail: dell'italia{at}physiology.uab.edu.

In the current study interstitial fluid (ISF) bradykinin (BK) and angiotensin II (ANG II) levels were measured using cardiac microdialysis in conscious, non-sedated rats at baseline, at 48 hours and 5 days following: sham surgery (Sham, n=6), Sham+ACE inhibitor ramipril (R) (n=6), aorto-caval fistula (ACF) (n=6), and ACF+R (n=6), and ACF+R+BK2 receptor antagonist (HOE140) (n=6). At 5 days both ISF ANG II and BK increased in ACF rats (p<0.05); however, in ACF+R, ISF ANG II did not differ from basal levels and ISF BK increased greater than 3-fold above baseline at 2 and 5 days (p<0.05). Five days after ACF, LV weight/body weight increased 30% (p<0.05) in ACF but did not differ from Sham in ACF+R rats and ACF+R+HOE140, in spite of similar systemic arterial pressures across all ACF groups. However, ACF+R+HOE140 rats had greater post-mortem wall thickness/diameter and smaller cross-sectional diameter compared to ACF+R rats. There was a significant increase in mast cell density in ACF, ACF+R rats that decreased below Sham in ACF+R+HOE140 rats. These results suggest a potentially important interaction of mast cells and BK in the cardiac interstitium that modulates the pattern of LV remodeling in the acute phase of volume overload.




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
H. C.G. Prosser, M. E. Forster, A. M. Richards, and C. J. Pemberton
Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics
Cardiovasc Res, April 1, 2009; 82(1): 40 - 50.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. A. Marsh, P. C. Powell, A. Agarwal, L. J. Dell'Italia, and J. C. Chatham
Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: role of hydronephrosis
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H292 - H298.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
C. M. McNicholas-Bevensee, K. B. DeAndrade, W. E. Bradley, L. J. Dell'Italia, P. A. Lucchesi, and M. O. Bevensee
Activation of gadolinium-sensitive ion channels in cardiomyocytes in early adaptive stages of volume overload-induced heart failure
Cardiovasc Res, November 1, 2006; 72(2): 262 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Iwata, R. T. Cowling, D. Gurantz, C. Moore, S. Zhang, J. X.-J. Yuan, and B. H. Greenberg
Angiotensin-(1-7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects
Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2356 - H2363.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.