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Articles in PresS, published online ahead of print November 21, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00793.2002
Submitted on September 9, 2002
Accepted on November 14, 2002
1 Dalton Cardiovascular Research Center and Department of Veterinary Biomedical Sciences, University of Missouri, Columbia, Missouri, USA
* To whom correspondence should be addressed. E-mail: xueb{at}missouri.edu.
This study reports the effects of angiotensin II (Ang II), arg-vasopression (AVP), phenylephrine (PE) and sodium-nitroprusside (SNP) on baroreflex control of heart rate in the presence and absence of the area postrema (AP) in conscious mice. In intact, sham lesioned mice, baroreflex induced decreases in heart rate due to increases in arterial pressure with intavenous infusions of Ang II were significantly less than those observed with similar increases in arterial pressure with PE (slope -3.0± 0.9 vs -8.1±1.5 beats/min/mmHg). Baroreflex induced decreases in heart rate due to increases in arterial pressure with intravenous infusions of AVP were the same as those observed with PE in sham animals (slope -5.8± 0.7 vs -8.1 ±1.5 beats/min/mmHg). Following lesioning of the AP, the slope of baroreflex inhibition of heart rate was the same whether pressure was increased with Ang II, AVP or PE. The slope of the baroreflex induced increases in heart rate due to decreases in arterial blood pressure with SNP were the same in sham and AP lesioned animals. These results indicate that similar to other species, in mice the ability of Ang II to acutely reset baroreflex control of heart rate is dependent on an intact AP.
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