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Am J Physiol Heart Circ Physiol (May 16, 2002). doi:10.1152/ajpheart.00802.2001
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Articles in PresS, published online ahead of print May 16, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00802.2001
Submitted on September 12, 2001
Accepted on May 6, 2002

Analysis of Right Ventricular Volumes and Systolic Function in Healthy Mice and a Murine Model of Heart Failure by In-Vivo MRI

Frank Wiesmann1*, Alex Frydrychowicz1, Judith Rautenberg1, Ralf Illinger1, Eberhard Rommel2, Axel Haase2, and Stefan Neubauer3

1 Universitaet Wuerzburg, Medizinische Klinik, Wuerzburg, Germany
2 Universitaet Wuerzburg, Physikalisches Institut, Wuerzburg, Germany
3 Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

* To whom correspondence should be addressed. E-mail: f.wiesmann{at}mail.uni-wuerzburg.de.

Due to its complex geometry, assessment of right ventricular (RV) function is more difficult than it its for the left ventricle (LV). As gene-targeted mouse models of cardiomyopathy may involve remodeling of the right heart, purpose of this study was to develop high resolution functional MRI for in vivo quantification of RV volumes and global function in mice. Thirtythree mice of various age were studied under Isoflurane anesthesia by ECG-triggered CINE-MRI at 7 T. MRI revealed close correlations between RV and LV stroke volume (SV) and cardiac output (r=0.97, p<0.0001 each). Consistent with human physiology, murine RV EDV and ESV were significantly higher compared to LV volumes (p<0.05 each). MRI in mice with left ventricular heart failure due to myocardial infarction revealed significant structural and functional changes of the right ventricle, indicating RV dysfunction. Hence, MRI allows for the quantification of RV volumes and global systolic function with high accuracy and bears the potential to evaluate mechanisms of RV remodeling in mouse models of heart failure.




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P. Pokreisz, G. Marsboom, and S. Janssens
Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited
Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H75 - H84.
[Abstract] [Full Text] [PDF]


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