AJP - Heart Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (May 16, 2002). doi:10.1152/ajpheart.00802.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/3/H1065    most recent
00802.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wiesmann, F.
Right arrow Articles by Neubauer, S.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Wiesmann, F.
Right arrow Articles by Neubauer, S.

Articles in PresS, published online ahead of print May 16, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00802.2001
Submitted on September 12, 2001
Accepted on May 6, 2002

Analysis of Right Ventricular Volumes and Systolic Function in Healthy Mice and a Murine Model of Heart Failure by In-Vivo MRI

Frank Wiesmann1*, Alex Frydrychowicz1, Judith Rautenberg1, Ralf Illinger1, Eberhard Rommel2, Axel Haase2, and Stefan Neubauer3

1 Universitaet Wuerzburg, Medizinische Klinik, Wuerzburg, Germany
2 Universitaet Wuerzburg, Physikalisches Institut, Wuerzburg, Germany
3 Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom

* To whom correspondence should be addressed. E-mail: f.wiesmann{at}mail.uni-wuerzburg.de.

Due to its complex geometry, assessment of right ventricular (RV) function is more difficult than it its for the left ventricle (LV). As gene-targeted mouse models of cardiomyopathy may involve remodeling of the right heart, purpose of this study was to develop high resolution functional MRI for in vivo quantification of RV volumes and global function in mice. Thirtythree mice of various age were studied under Isoflurane anesthesia by ECG-triggered CINE-MRI at 7 T. MRI revealed close correlations between RV and LV stroke volume (SV) and cardiac output (r=0.97, p<0.0001 each). Consistent with human physiology, murine RV EDV and ESV were significantly higher compared to LV volumes (p<0.05 each). MRI in mice with left ventricular heart failure due to myocardial infarction revealed significant structural and functional changes of the right ventricle, indicating RV dysfunction. Hence, MRI allows for the quantification of RV volumes and global systolic function with high accuracy and bears the potential to evaluate mechanisms of RV remodeling in mouse models of heart failure.




This article has been cited by other articles:


Home page
 Eur Heart J SupplHome page
P. Pokreisz, G. Marsboom, and S. Janssens
Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited
Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H75 - H84.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1976 by the American Physiological Society.