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1 Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA
* To whom correspondence should be addressed. E-mail: rkennedy{at}lumc.edu.
Several studies have examined the role of mast cells in the myocardial response to injury such as that caused by hypertension and ischemia/reperfusion. However, little is known about the influence of mast cells on normal myocardial structure and function. Current experiments examined cardiac function in Langendorff-perfused hearts isolated from 6 and 9 mo-old, male, mast cell deficient (Ws/Ws) and mast cell competent rats. A fluid-filled balloon catheter was used to measure left ventricular (LV) diastolic and systolic function at increasing preload volumes. At 6 mo of age, mast cell deficient rats showed a slight cardiac hypertrophy (as monitored by heart weight and heart/body weight ratio) but no significant change in maximum observed systolic or diastolic function. In contrast, at 9 mo of age the mast cell deficient group showed no signs of hypertrophy but displayed a diastolic dysfunction characterized by decreased compliance without a significant decline in maximum observed basal -dP/dtmax. There were no significant differences in maximum observed values for measures of systolic function (developed pressure and +dP/dtmax). In summary, results of this study in adult rats suggest that mast cells influence cardiac function in the absence of injury, and that observed differences between mast cell competent and deficient animals vary with age. Thus, it is important to consider these physiological actions and resulting changes in function when studying effects of insult in mast cell deficient models.
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