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1 Service de Physiologie EFCR, Hopitaux de Paris, Le Kremlin-Bicetre, France; UPRES, 2705Universite Paris Sud 11, Clamart, France
2 Service de Physiologie et d'Explorations Fonctionnelles, Hopitaux de Paris, Bondy, France
3 Service de Physiologie EFCR, Hopitaux de Paris, Le Kremlin-Bicetre, France
* To whom correspondence should be addressed. E-mail: denis.chemla{at}bct.ap-hop-paris.fr.
The respective contribution of systemic vascular resistance (R) and total arterial compliance (C) to the arterial load remains to be established in humans. Effective arterial elastance (Ea), i.e., the left ventricular end-systolic pressure (LVESP) over stroke volume ratio, is a reliable estimate of arterial load. It is widely accepted that Ea mainly relates to mean aortic pressure (MAP) and thus to R/T, where T is cycle length. We tested the contribution of R/T and 1/C to Ea in 20 normotensive and 46 hypertensive subjects (MAP range: 84-160 mmHg). The multilinear model applied (Ea=1.00R/T+0.42/C-0.04; r2=0.97). The R/T ratio contributed 2.5 times more to Ea than 1/C in both normotensive and hypertensive adults. The LVESP was more strongly related to systolic aortic pressure (SAP; r2=0.94) than to MAP (r2=0.83), and LVESP matched 90%SAP (bias=0±/-5mmHg). An alternative model of Ea is proposed in which Ea is proportional to the (heart rate x SAP) product over cardiac index ratio whatever the MAP.
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