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1 Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN, USA
* To whom correspondence should be addressed. E-mail: hend0450{at}umn.edu.
Previous studies have clearly demonstrated acute actions of angiotensin II (ANG II) at one of the central circumventricular organs, the subfornical organ (SFO), but studies demonstrating a role of the SFO in the chronic actions of ANG II remain uncertain. The purpose of this study was to examine the role of the SFO in the chronic hypertensive phase of ANG II induced hypertension. We hypothesized that the SFO is necessary for the full hypertensive response observed during the chronic phase of ANG II induced hypertension. In order to test this hypothesis, male Sprague Dawley rats were subjected to either sham operation (SHAM) or electrolytic lesion of the SFO (SFOx). One week later, rats were instrumented with venous catheters, and radio-telemetric transducers for the intravenous administration of ANG II and the measurement of blood pressure and heart rate respectively. Rats were then given a week recovery period. After 3 days of saline control infusion (7 ml 0.9% NaCl/day), ANG II was intravenously infused at a rate of 10 ng/kg/min in both SHAM and SFOx animals for 10 consecutive days, and followed by 3 recovery days. A 0.4% NaCl diet and distilled water were provided ad libitum. By day 5 of ANG II infusion, MAP had increased 11.7±3.0 mmHg in SHAM rats (n=9), but had only increased 3.7±1.4 mmHg in SFOx rats (n=9). This trend continued through day 10 of ANG II treatment. These results support the hypothesis that the SFO is necessary for the full hypertensive response to chronic ANG II administration.
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