| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print December 12, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00834.2002
Submitted on September 18, 2002
Accepted on December 4, 2002
1 Center for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA, USA
* To whom correspondence should be addressed. E-mail: lzhang{at}som.llu.edu.
Cortisol potentiated NE-mediated contractions in ovine uterine arteries. We tested the hypothesis that cortisol regulated 
1-adrenoceptor-mediated pharmacomechanical coupling differentially in nonpregnant (NUA) and pregnant (PUA) uterine arteries. Cortisol (10 ng/ml for 24h) significantly increased contractile coupling efficiency of 1-adrenoceptors in NUA, but increased 1-adrenoceptor density in PUA. Cortisol potentiated NE-induced inositol 1,4,5-trisphosphate (InsP3) synthesis in both NUA and PUA, but increased coupling efficiency of 1-adrenoceptors to InsP3 synthesis only in NUA. Carbenoxolone alone did not affect NE-mediated InsP3 production, but significantly enhanced cortisol-mediated potentiation of NE stimulated InsP3 synthesis in PUA. In addition, cortisol potentiated NE-induced increase in Ca2+ concentration in PUA, but increased NE-mediated contraction for a given amount of Ca2+ concentration in NUA. Collectively, the results indicate that cortisol potentiates NE-mediated contractions differentially in NUA and PUA, i.e. by up-regulating 1-adrenoceptor density leading to increased Ca2+ mobilization in PUA, whereas by increasing 1-adrenoceptor coupling efficiency and myofilament Ca2+ sensitivity in NUA. In addition, the results suggest that pregnancy increases type 2 11
-hydroxysteroid dehydrogenase activity in the uterine arteries.
This article has been cited by other articles:
|
|
 |
|
  A. E. Michael and A. T. Papageorghiou Potential significance of physiological and pharmacological glucocorticoids in early pregnancy Hum. Reprod. Update, September 1, 2008; 14(5): 497 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Chang and Lubo Zhang Review Article: Steroid Hormones and Uterine Vascular Adaptation to Pregnancy Reproductive Sciences, April 1, 2008; 15(4): 336 - 348. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Xiao, J. N. Buchholz, and L. Zhang Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2337 - H2343. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Gnanalingham, D. A. Giussani, P. Sivathondan, A. J. Forhead, T. Stephenson, M. E. Symonds, and D. S. Gardner Chronic umbilical cord compression results in accelerated maturation of lung and brown adipose tissue in the sheep fetus during late gestation Am J Physiol Endocrinol Metab, September 1, 2005; 289(3): E456 - E465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao and L. Zhang Adaptation of uterine artery thick- and thin-filament regulatory pathways to pregnancy Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H142 - H148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Xiao and L. Zhang Calcium Homeostasis and Contraction of the Uterine Artery: Effect of Pregnancy and Chronic Hypoxia Biol Reprod, April 1, 2004; 70(4): 1171 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, X. Huang, S. Bae, C. A. Ducsay, L. D. Longo, and L. Zhang Cortisol-mediated regulation of uterine artery contractility: effect of chronic hypoxia Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H716 - H722. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
