| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print November 27, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00835.2002
Submitted on September 18, 2002
Accepted on November 25, 2002
1 Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
* To whom correspondence should be addressed. E-mail: jlombard{at}mcw.edu.
Male Sprague Dawley rats were maintained on a low salt (LS) diet (0.4 % NaCl) or a (high salt) HS diet (4% NaCl) for 3 days or 4 weeks. PO2 reduction to 40-45 mmHg, the stable prostacyclin analogue iloprost (10 pg/ml), and Gs protein activation with cholera toxin (1 ng/ml) caused vascular smooth muscle (VSM) hyperpolarization, increased cAMP production, and dilation in cerebral arteries from rats on LS diet. Arteries from rats on HS diet exhibited VSM depolarization and constriction in response to hypoxia and iloprost, failed to dilate or hyperpolarize in response to cholera toxin, and cAMP production did not increase in response to hypoxia, iloprost, or cholera toxin. Low dose angiotensin II infusion (5 ng/kg/min, i.v.) restored normal responses to reduced PO2 and iloprost in arteries from animals on a HS diet. These observations suggest that angiotensin II suppression with HS diet leads to impaired relaxation of cerebral arteries in response to vasodilator stimuli acting at the cell membrane.
This article has been cited by other articles:
|
|
 |
|
  M. P. Kunert, M. R. Dwinell, I. Drenjancevic Peric, and J. H. Lombard Sex-specific differences in chromosome-dependent regulation of vascular reactivity in female consomic rat strains from a SS x BN cross Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2008; 295(2): R516 - R527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Marvar, J. R. Falck, and M. A. Boegehold High dietary salt reduces the contribution of 20-HETE to arteriolar oxygen responsiveness in skeletal muscle Am J Physiol Heart Circ Physiol, March 1, 2007; 292(3): H1507 - H1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Kunert, I. Drenjancevic-Peric, M. R. Dwinell, J. H. Lombard, A. W. Cowley Jr., A. S. Greene, A. E. Kwitek, and H. J. Jacob Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat Physiol Genomics, September 14, 2006; 26(3): 218 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhu, I. Drenjancevic-Peric, S. McEwen, J. Friesema, D. Schulta, M. Yu, R. J. Roman, and J. H. Lombard Role of superoxide and angiotensin II suppression in salt-induced changes in endothelial Ca2+ signaling and NO production in rat aorta Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H929 - H938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Phillips, E. B. Olson, J. H. Lombard, and B. J. Morgan Chronic intermittent hypoxia alters NE reactivity and mechanics of skeletal muscle resistance arteries J Appl Physiol, April 1, 2006; 100(4): 1117 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Drenjancevic-Peric, S. A. Phillips, J. R. Falck, and J. H. Lombard Restoration of normal vascular relaxation mechanisms in cerebral arteries by chromosomal substitution in consomic SS.13BN rats Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H188 - H195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, R. J. Roman, J. R. Falck, L. de la Cruz, and J. H. Lombard Effects of high-salt diet on CYP450-4A {omega}-hydroxylase expression and active tone in mesenteric resistance arteries Am J Physiol Heart Circ Physiol, April 1, 2005; 288(4): H1557 - H1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhu, M. Yu, J. Friesema, T. Huang, R. J. Roman, and J. H. Lombard Salt-induced ANG II suppression impairs the response of cerebral artery smooth muscle cells to prostacyclin Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H908 - H913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Phillips, I. Drenjancevic-Peric, J. C. Frisbee, and J. H. Lombard Chronic AT1 receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H545 - H552. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Drenjancevic-Peric and J. H. Lombard Introgression of chromosome 13 in Dahl salt-sensitive genetic background restores cerebral vascular relaxation Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H957 - H962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhu, T. Mori, T. Huang, and J. H. Lombard Effect of high-salt diet on NO release and superoxide production in rat aorta Am J Physiol Heart Circ Physiol, February 1, 2004; 286(2): H575 - H583. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
