| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print February 21, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00860.2001
Submitted on October 3, 2001
Accepted on February 19, 2002
1 Cardiological Sciences, St. George's Hospital Medical School, London, United Kingdom
* To whom correspondence should be addressed. E-mail: m.malik{at}sghms.ac.uk.
Recently, it has been demonstrated that the QT/RR relationship pattern varies significantly between healthy individuals. This study compared the intra- and inter-individual variations of the QT/RR relationship.
Methods: 24-hour 12-lead digital ECGs (SEER MC, GE Marquette, 10-second ECG recorded every 30 seconds) were obtained at baseline, after 24 hours, 1 week and 1 month in 75 healthy subjects (42 female, 33 male, age 27.9±9.6 vs 26.8±7.5 years, p=NS). QT interval was measured automatically in each ECG by 6 different algorithms and the mean of the 6 measurements was analysed. In each recording of each individual, the QT/RR relationship was assessed by 10 different regression models including the linear (QT=
+ßxRR) and parabolic (QT=ßxRR) models. The standard deviations (SD) of the regression parameters and ß of consecutive recordings of each individual were compared with the SD of the individual means. The intra-subject stability and inter-individual variability were further tested by ANOVA.
Results: With all models, the intra-individual SDs of the regression parameters were highly significantly smaller than SD of individual means (p<10-5-10-9). The intra-subject stability was further confirmed by ANOVA (p<10-19-10-30).
Conclusions: The QT/RR relationship exhibits substantial inter-subject variability as well as a high intra-subject stability. This has practical implications for a precise estimation of the heart rate-corrected QT interval in which optimised subject-specific rate-correction formulae should be used.
This article has been cited by other articles:
|
|
 |
|
  M. Malik, K. Hnatkova, A. Schmidt, and P. Smetana Electrocardiographic QTc Changes Due to Moxifloxacin Infusion J. Clin. Pharmacol., June 1, 2009; 49(6): 674 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Odening, O. Hyder, L. Chaves, L. Schofield, M. Brunner, M. Kirk, M. Zehender, X. Peng, and G. Koren Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2264 - H2272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Malik, K. Hnatkova, T. Novotny, and G. Schmidt Subject-specific profiles of QT/RR hysteresis Am J Physiol Heart Circ Physiol, December 1, 2008; 295(6): H2356 - H2363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Malik, K. Hnatkova, J. Ford, and D. Madge Near-Thorough QT Study as Part of a First-In-Man Study J. Clin. Pharmacol., October 1, 2008; 48(10): 1146 - 1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Goldberger, M. E. Cain, S. H. Hohnloser, A. H. Kadish, B. P. Knight, M. S. Lauer, B. J. Maron, R. L. Page, R. S. Passman, D. Siscovick, et al. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death: A Scientific Statement From the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention J. Am. Coll. Cardiol., September 30, 2008; 52(14): 1179 - 1199. [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Goldberger, M. E. Cain, S. H. Hohnloser, A. H. Kadish, B. P. Knight, M. S. Lauer, B. J. Maron, R. L. Page, R. S. Passman, D. Siscovick, et al. American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death: A Scientific Statement From the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention Circulation, September 30, 2008; 118(14): 1497 - 1518. [Full Text] [PDF]
|
|
|
|
|
|
S. Sundaram, M. Carnethon, K. Polito, A. H. Kadish, and J. J. Goldberger Autonomic effects on QT-RR interval dynamics after exercise Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H490 - H497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Chan, G.K. Isbister, C.M.J. Kirkpatrick, and S.B. Dufful Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram QJM, October 1, 2007; 100(10): 609 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Kowey and M. Malik The QT interval as it relates to the safety of non-cardiac drugs Eur. Heart J. Suppl., September 1, 2007; 9(suppl_G): G3 - G8. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Robert, M. Salva, R. Segarra, M. Pavesi, R. Esbri, D. Roberts, and G. Golor The Prokinetic Cinitapride Has No Clinically Relevant Pharmacokinetic Interaction and Effect on QT during Coadministration with Ketoconazole Drug Metab. Dispos., July 1, 2007; 35(7): 1149 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Ballo, D. Bernabo, and S. A. Faraguti Abnormal QT responses to adenosine in subjects with long-QT syndrome Eur. Heart J., July 2, 2006; 27(14): 1759 - 1760. [Full Text] [PDF]
|
|
|
|
 |
|
 P. Smetana, V. Batchvarov, K. Hnatkova, A John Camm, and M. Malik Sex differences in the rate dependence of the T wave descending limb Cardiovasc Res, June 1, 2003; 58(3): 549 - 554. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
