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Articles in PresS, published online ahead of print December 5, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00864.2002
Submitted on October 4, 2002
Accepted on November 26, 2002
1 Groupe Rein et Hypertension, Universite Montpellier I, Montpellier, France
2 Laboratoire de Nutrition et Atherogenese, Universite Montpellier I, Montpellier, France
* To whom correspondence should be addressed. E-mail: jover{at}iurc.montp.inserm.fr.
The influence of a low sodium (LS) diet was assessed on the cardiac and renal alterations and pro-oxidant effect associated with a 10-day infusion of angiotensin II (200 or 400 ng.kg-1.min-1, osmotic pumps). Tail-cuff pressure (TCP), albuminuria and renal blood flow were determined at the end of experiments. Heart weight index (HWI) and production of superoxide anion (O2°-) by the left ventricle and hydrogen peroxide (H202) by the aorta was measured by bioluminescence. Although final TCP was similar in LS and normal sodium rats infused with the high and low dose of angiotensin II, respectively, the increase in HWI was prevented by the LS diet. Sodium restriction reduced the rise in albuminuria without change in the renal effect of angiotensin II. The increased production of O2°- and H2O2 observed in NS rats was abrogated in LS rats. The beneficial influence of dietary sodium restriction on target organ damage induced by angiotensin II is independent of arterial pressure reduction and possibly related to attenuation of the pro-oxidant effect of the peptide.
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