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1 Department of Medicine, Washington University, St. Louis, MO, USA; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA
2 Department of Chemistry and Radiology, Washington University, St. Louis, MO, USA
3 Department of Medicine, Washington University, St. Louis, MO, USA
* To whom correspondence should be addressed. E-mail: xin{at}cvu.wustl.edu.
Structural remodeling of myocardium after infarction plays a critical role in functional adaptation. Diffusion tensor MRI (DTMRI) provides a means for rapid and nondestructive characterization of the three-dimensional fiber architecture of cardiac tissues. In this study, microscopic structural changes caused by myocardial infarction were evaluated in Fischer 344 rats 4 weeks after infarct surgery. DTMRI studies were performed on 15 excised, formalin-fixed rat hearts of both infarct (LAD occlusion, n=8) and control (sham, n=7). Infarct myocardium exhibited increased water diffusivity (41% increase in trace values), and decreased diffusion anisotropy (37% decrease in relative anisotropy index). The reduced diffusion anisotropy correlated negatively with microscopic fiber disarray determined by histologic analysis (R=0.81). Transmural courses of fiber orientation angles in infarct zones were similar to those of normal myocardium. However, regional angular deviation of the diffusion tensor increased significantly in infarct myocardium, and correlated strongly with microscopic fiber disarray (R=0.86). These results suggest that DTMRI may provide a valuable tool for defining structural remodeling in diseased myocardium at the cellular and tissue level.
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