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1 Department of Physiology, East Tennessee State University, Johnson City, TN, USA
2 Department of Pharmacology, East Tennessee State University, Johnson City, TN, USA
* To whom correspondence should be addressed. E-mail: williams{at}mail.etsu.edu.
Anti-body coated microprobes were inserted into the thoracic (T3-4) spinal cord in urethane-anesthetized Sprague-Dawley rats to detect the differences in the release of immunoreactive SP-like substances (irSP) in response to differential activation of cardiac nociceptive sensory neurons (CNAN). CNAN were stimulated either by intra-pericardial infusion of an "inflammatory exudate solution" (IES) containing algogenic substances (i.e., 10 mM each of adenosine, bradykinin, prostaglandin E2 and 5-hydroxytryptamine), or by transient occlusion of the left anterior descending coronary artery (CoAO). There was widespread basal release of irSP from thoracic spinal cord. Stimulation of the CNAN by IES did not alter the pattern of release of irSP. Conversely, CoAO augmented the release of irSP from T3-4 spinal segments from laminae I-VII. This CoAO induced irSP release was eliminated following thoracic dorsal rhizotomy. These results indicate that heterogeneous activation of cardiac afferents, as with focal coronary artery occlusion, represents an optimum input for activation of the cardiac neuronal hierarchy and for the resultant perception of angina. Excessive stimulation of cardiac nociceptive afferent neurons elicited during regional coronary artery occlusion involves the release of SP in the thoracic spinal cord and suggests that local spinal cord release of SP may be involved in the neural signaling of angina.
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