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Am J Physiol Heart Circ Physiol (November 20, 2003). doi:10.1152/ajpheart.00913.2003
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Submitted on September 25, 2003
Accepted on November 12, 2003

Microlymphatic and tissue oxygen tension in the rat mesentery

Nanae Hangai-Hoger1*, Pedro Cabrales1, Juan C. Briceno2, Amy G. Tsai1, and Marcos Intaglietta1

1 Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
2 Department of Mechanical Engineering, University de los Andes, Bogota, Colombia

* To whom correspondence should be addressed. E-mail: nhangai{at}bioeng.ucsd.edu.

Oxygen phosphorescence quenching was used to measure tissue oxygen tension (pO2) of lymphatic vessels of 43.6 ± 23.1µm (mean ± SD) diameter in tissue locations of the rat mesentery classified according to anatomical location. Lymph and adipose tissue pO2 were 20.6 ± 9.1 mmHg and 34.1 ± 7.8 mmHg respectively, the difference being statistically significant. Rare microlymphatic vessels in connective tissue not surrounded by microvessels had pO2 of 0.8 ± 0.2 mmHg, while the surrounding tissue pO2 was 3.0 ± 3.2 mmHg, both values being significantly lower than adipose tissue. Lower of lymph fluid pO2 relative to the surrounding tissue was also evident in paired measurements of pO2 in the lymphatic vessels and peri lymphatic adipose tissue, which was significantly lower than the pO2 in the paired adipose tissue. The pO2 of the lymphatic fluid of the mesenteric micro-lymphatics is consistently lower than that of the surrounding adipose tissue by about 11 mmHg, therefore lymph fluid has the lowest oxygen tension of this tissue. The disparity between lymph and tissue pO2 is attributed to micro lymphatic vessel wall and lymphocytes oxygen consumption.




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