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Am J Physiol Heart Circ Physiol (August 8, 2002). doi:10.1152/ajpheart.00933.2001
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Articles in PresS, published online ahead of print August 8, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.00933.2001
Submitted on November 1, 2001
Accepted on August 6, 2002

An integrative model of coupled water and solute exchange in the heart

Michael R Kellen1 and James B Bassingthwaighte1*

1 Bioengineering, University of Washington, Seattle, WA, USA

* To whom correspondence should be addressed. E-mail: jbb{at}bioeng.washington.edu.

Physiologists have devised many models for interpreting water and solute exchange data in whole organs, but the models have typically neglected key aspects of the underlying physiology to present the simplest possible model for a given experimental situation. We have developed a physiologically realistic model of microcirculatory water and solute exchange and applied it to diverse observations on water and solute exchange in the heart. Model simulations are consistent with the results of osmotic weight transient, tracer indicator dilution, and steady-state lymph sampling experiments. The key model features that permit this unification are the use of an axially-distributed blood-tissue exchange region, inclusion of a lymphatic drain in the interstitium, and the independent computation of transcapillary solute and solvent fluxes through three different pathways.




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