AJP - Heart Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (July 8, 2005). doi:10.1152/ajpheart.00934.2004
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
289/5/H2048    most recent
00934.2004v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (54)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holzapfel, G. A
Right arrow Articles by Regitnig, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holzapfel, G. A
Right arrow Articles by Regitnig, P.
Submitted on September 7, 2004
Accepted on May 21, 2005

Determination of the layer-specific mechanical properties ofhuman coronary arteries with intimal thickening, and related constitutive modelling

Gerhard A Holzapfel1*, Gerhard Sommer1, Christian Gasser1, and Peter Regitnig2

1 Graz University of Technology, Institute of Computational Biomechanics, Graz, Austria
2 Medical University Graz, Institute of Pathology, Graz, Austria

* To whom correspondence should be addressed. E-mail: gh{at}biomech.tu-graz.ac.at.

At autopsy 13 non-stenotic human left anterior descending (LAD) coronary arteries (71.5 ± 7.3yr, mean±SD) were harvested and related anamnesis documented. Cyclic quasistatic uniaxial tension tests of 78 pre-conditioned prepared strips of mid-LAD segments from the individual layers in the axial and circumferential directions were performed; ultimate tensile stresses and stretches were documented. The ratio of outer diameter to total wall thickness was 0.189 ± 0.014; ratios between thickness of adventitia, media, intima and the total wall were 0.4 ± 0.03, 0.36 ± 0.03, 0.27 ± 0.02; axial in situ stretch was 1.044 ± 0.06, and decreased with age. The stress-stretch responses for the individual tissues showed pronounced mechanical heterogeneity. The intima is the stiffest layer over the whole deformation domain, while the media in the longitudinal direction is the softest. All specimens exhibited small hysteresis, behaved anisotropically and strongly nonlinearly in both loading directions. The media and intima showed similar ultimate tensile stresses, which are on average three times smaller than ultimate tensile stresses in the adventitia (1430 ± 604kPa circumferential, 1300 ± 692kPa longitudinal). The ultimate tensile stretches are similar for all tissue layers. A recently proposed constitutive model was extended and used to represent the deformation behavior for each tissue type over the entire loading range. The study showed the need to model non-stenotic human coronary arteries with non-atherosclerotic intimal thickening as a composite-structure composed of three solid mechanically relevant layers exhibiting different mechanical properties. The intima showed significant thickness, load-bearing capacity and mechanical strength when compared with the media and adventitia.




This article has been cited by other articles:


Home page
 J R Soc InterfaceHome page
G. A. Holzapfel and R. W. Ogden
Modelling the layer-specific three-dimensional residual stresses in arteries, with an application to the human aorta
J R Soc Interface, October 14, 2009; (2009) rsif.2009.0357v1.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. C. Schumacher, P. M. Meyers, R. T. Higashida, C. P. Derdeyn, S. D. Lavine, G. M. Nesbit, D. Sacks, P. Rasmussen, and L. R. Wechsler
Reporting Standards for Angioplasty and Stent-Assisted Angioplasty for Intracranial Atherosclerosis
Stroke, May 1, 2009; 40(5): e348 - e365.
[Abstract] [Full Text] [PDF]

Home page
 Eur. J. Cardiothorac. Surg.Home page
A. Zhao, M. L. Field, K. Digges, and D. Richens
Blunt trauma and acute aortic syndrome: a three-layer finite-element model of the aortic wall
Eur. J. Cardiothorac. Surg., September 1, 2008; 34(3): 623 - 629.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Ohayon, G. Finet, A. M. Gharib, D. A. Herzka, P. Tracqui, J. Heroux, G. Rioufol, M. S. Kotys, A. Elagha, and R. I. Pettigrew
Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture
Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H717 - H727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Wang, W. Zhang, and G. S. Kassab
The validation of a generalized Hooke's law for coronary arteries
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H66 - H73.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Ohayon, O. Dubreuil, P. Tracqui, S. Le Floc'h, G. Rioufol, L. Chalabreysse, F. Thivolet, R. I. Pettigrew, and G. Finet
Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture
Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1987 - H1996.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. Zhang, Y. Liu, and G. S. Kassab
Flow-induced shear strain in intima of porcine coronary arteries
J Appl Physiol, August 1, 2007; 103(2): 587 - 593.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1977 by the American Physiological Society.