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1 Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA
2 The Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA
3 The Clinical Nutrition Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
4 Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, USA; The Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL, USA
* To whom correspondence should be addressed. E-mail: jchatham{at}uab.edu.
The goal of this study was to determine whether changes in cardiac metabolism in Type-2 diabetes were associated with contractile dysfunction or impaired response to ischemia. Hearts from Zucker diabetic fatty rats (ZDF) and lean Controls were isolated, perfused and glucose, lactate, pyruvate and palmitate oxidation rates and glycolytic rates determined during baseline perfusion, low flow ischemia (LFI; 0.3mls/min for 30min) and following LFI and reperfusion. Under all conditions, ATP synthesis from palmitate was increased and that from lactate was decreased in the ZDF group, whereas the contribution from glucose was unchanged. During baseline perfusion glycolysis was lower in the ZDF group; however, during LFI and reperfusion there were no differences between groups. Despite these metabolic shifts there were no differences in oxygen consumption or ATP production rates between the groups under any perfusion conditions. Cardiac function was slightly depressed prior to LFI in the ZDF group but during reperfusion function was improved relative to controls despite the increased dependence on fatty acids for energy production. These data suggest that in this model of diabetes the shift from carbohydrates to fatty acids for oxidative energy production did not increase myocardial oxygen consumption and was not associated with impaired response to ischemia and reperfusion.
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