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1 Laboratory of Haemodynamics and Cardiovascular Technology, EPFL, Lausanne, Switzerland; Department of Cardiovascular Surgery, CHUV, Lausanne, Switzerland
2 Department of Cardiology, CHUV, Lausanne, Switzerland
3 Department of Anaesthesiology, CHUV, Lausanne, Switzerland
4 Laboratory of Haemodynamics and Cardiovascular Technology, EPFL, Lausanne, Switzerland
5 Department of Cardiovascular Surgery, Inselspital, Bern, Switzerland
6 Department of Cardiovascular Surgery, CHUV, Lausanne, Switzerland
7 Hydraulics Laboratory, Institute of Biomedical Technology, Ghent University, Gent, Belgium
* To whom correspondence should be addressed. E-mail: David.Jegger{at}epfl.ch.
The rodent model of myocardial infarction (MI) is extensively used in heart failure (HF) studies. However, long term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the fractional shortening (LVFS/MPI), has not been validated in conjunction with invasive indices, such as those derived from the conductance catheter (CC). Sprague-Dawley rats with LAD coronary artery ligation (MI group, n=9) were compared to a sham operated control group (CTRL group, n=10) without MI. TTE was performed every 2 weeks over an 8 week period, after which classical TTE parameters, specially MPI and LVFS/MPI were compared to invasive indexes obtained using a CC. Serial TTE data showed significant alterations in the majority of the noninvasive functional and structural parameters (classic and novel) studied in the presence of MI. Both MPI and LVFS/MPI significantly (all reported values p<0.05) correlated with body weight (r=-0.58 and 0.76 for MPI and LVFS/MPI, respectively), preload recruitable stroke work (r=-0.61 and 0.63), LV end-diastolic pressure (LVEDP) (r=0.82 and -0.80), end-diastolic volume (r=0.61 and -0.58) and end-systolic volume (r=0.46 and -0.48). Forward stepwise linear regression analysis revealed that, of all variables tested, LVEDP was the only independent determinant of MPI (r=0.84) and LVFS/MPI (r=0.83). We conclude that MPI and LVFS/MPI correlate strongly and better, than the classic noninvasive TTE parameters, with established invasively assessed indexes of contractility, preload and volumetry. These findings support the use of these two new noninvasive indexes for long-term analysis of the post-MI LV remodeling.
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