| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Kinesiology and Health Education, University of Texas, Austin, TX, USA
* To whom correspondence should be addressed. E-mail: jstarnes{at}mail.utexas.edu.
Exercise improves cardioprotection against ischemia-reperfusion in young animals, but has not been investigated in older animals that represent the population most likely to suffer an ischemic event. Therefore, we sought to determine the effects of aging on exercise-induced cardioprotection. Young, middle-aged, and old (4-, 12-, and 21-month-old) male F344 rats ran 60 min at 70-75% VO2max. 24h postexercise, isolated perfused working hearts underwent 22.5 min of global ischemia then 30 min of recovery (reperfusion). Compared to sedentary (n=8-9/gp), recovery of function (cardiac output x systolic pressure) improved after exercise (n=9/gp) by 40% at 4mo, 78% at 12mo, and 59% at 21mo. Exercise increased inducible heat shock protein 70 expression 105% at 4mo, but only 27% at 12mo and 24% at 21mo. Catalase activity progressively increased with age (P<0.05) and was increased by exercise at 4mo (26%) and 21mo (19%). Manganese superoxide dismutase activity was increased by exercise only at 21mo (45%). No exercise-related change in any antioxidant enzyme was observed at 12mo. We conclude that exercise can enhance cardioprotection regardless of age, but the cardioprotective protein phenotype changes with age.
This article has been cited by other articles:
|
|
 |
|
  K. Boengler, R. Schulz, and G. Heusch Loss of cardioprotection with ageing Cardiovasc Res, July 15, 2009; 83(2): 247 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. N. Peart and J. P. Headrick Clinical cardioprotection and the value of conditioning responses Am J Physiol Heart Circ Physiol, June 1, 2009; 296(6): H1705 - H1720. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Lawler, H.-B. Kwak, J.-H. Kim, and M.-H. Suk Exercise training inducibility of MnSOD protein expression and activity is retained while reducing prooxidant signaling in the heart of senescent rats Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1496 - R1502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Brown and R. L. Moore Perspectives in innate and acquired cardioprotection: cardioprotection acquired through exercise J Appl Physiol, November 1, 2007; 103(5): 1894 - 1899. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Taylor, M. E. Olsen, and J. W. Starnes Improved postischemic function following acute exercise is not mediated by nitric oxide synthase in the rat heart Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H601 - H607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lawler, H.-B. Kwak, W. Song, and J. L. Parker Exercise training reverses downregulation of HSP70 and antioxidant enzymes in porcine skeletal muscle after chronic coronary artery occlusion Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1756 - R1763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Lujan, S. L. Britton, L. G. Koch, and S. E. DiCarlo Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2933 - H2941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Reger, M. F. Barbe, M. Amin, B. F. Renna, L. A. Hewston, S. M. MacDonnell, S. R. Houser, and J. R. Libonati Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension J Appl Physiol, February 1, 2006; 100(2): 541 - 547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Starnes, A. M. Choilawala, R. P. Taylor, M. J. Nelson, and M. D. Delp Myocardial Heat Shock Protein 70 Expression in Young and Old Rats After Identical Exercise Programs J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2005; 60(8): 963 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hwang, P. J. Reiser, and G. E. Billman Effects of exercise training on contractile function in myocardial trabeculae after ischemia-reperfusion J Appl Physiol, July 1, 2005; 99(1): 230 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A Brown, J. M Lynch, C. J Armstrong, N. M Caruso, L. B Ehlers, M. S Johnson, and R. L Moore Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat J. Physiol., April 15, 2005; 564(2): 619 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Brown, K. N. Jew, G. C. Sparagna, T. I. Musch, and R. L. Moore Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart J Appl Physiol, December 1, 2003; 95(6): 2510 - 2518. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
