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1 Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
2 Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA; La Jolla Bioengineering Institute, La Jolla, CA, USA
3 Department of Anesthesia and Critical Care Medicine, The Leopold-Franzens-University of Innsbruck, Innsbruck, Austria
* To whom correspondence should be addressed. E-mail: nhangai{at}bioeng.ucsd.edu.
The microvascular distribution of oxygen was studied in the arterioles and venules of the awake hamster window chamber preparation to determine the contribution of vascular smooth muscle relaxation to oxygen consumption of the microvascular wall during Verapamil induced vasodilatation. Verapamil HCL delivered in a 0.1mg/kg bolus injection followed by a continuous infusion of 0.01 mg/kg/min caused significant arteriolar dilatation, increased microvascular flow and functional capillary density, and decreased arteriolar vessel wall transmural pO2 difference. Verapamil caused tissue pO2 to increase from 25.5 ± 4.1 mmHg during control to 32.0 ± 3.7 mmHg during Verapamil treatment. Total oxygen released by the microcirculation to the tissue remained the same as in baseline. Maintenance of the same level of oxygen release to the tissue, increased tissue pO2 and decreased wall oxygen concentration gradient are compatible if vasodilatation significantly lowers vessel wall oxygen consumption, which in this model appears to constitute an important oxygen consuming compartment. These findings show that treatment with Verapamil, which increases oxygen supply through vasodilatation, may further improve tissue oxygenation by lowering oxygen consumption of the microcirculation.
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