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1 Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, United States
* To whom correspondence should be addressed. E-mail: thomasj{at}ccf.org.
Left ventricular (LV) untwisting starts early during the isovolumic relaxation phase and proceeds throughout the early filling phase, releasing elastic energy stored by the preceding systolic deformation. Data relating untwisting, relaxation, and intraventricular pressure gradients (IVPG) which represent another manifestation of elastic recoil, are sparse. To understand the interaction between LV mechanics and inflow during early diastole, Doppler tissue images (DTI) and catheter-derived pressures (apical and basal LV, left atrial, and aortic) and LV volume data were obtained at baseline, during varying pacing modes, and during dobutamine and esmolol infusion in 7 closed-chest anesthetized dogs. LV torsion and torsional rate profiles were analyzed from DTI data sets (apical and basal short-axis images) with high temporal resolution (6.5±0.7 ms). Repeated measures regression models showed moderately strong correlation of peak LV twisting with peak LV untwisting rate (r=0.74), as well as correlations of peak LV untwisting rate with the time constant of LV pressure decay (tau, r=-0.66) and IVPG (r=0.76, p<0.0001 for all). In a multivariate analysis, peak LV untwisting rate was an independent predictor of tau and IVPG (p<0.0001, for both). The start of LV untwisting coincided with the beginning of relaxation and preceded suction-aided filling due to elastic recoil. Untwisting rate may be a useful marker of diastolic function or even serve as therapeutic target for improving diastolic function.
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