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1 Department of Integrative Physiology, University of North Texas Health Science Center, Fort Worth, Texas, USA
2 Presbyterian Hospital of Dallas, Institute for Exercise and Environmental Medicine, Dallas, Texas, USA
3 Copenhagen Muscle Research Center, Department of Anesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: Sogoh{at}hsc.unt.edu.
Exercise challenges cerebral autoregulation (CA) by a large increase in pulse pressure (PP) that may make systolic pressure exceed what is normally considered the upper range of CA. This study examined the relationship between systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP) and systolic (MCAVs), diastolic (MCAVd) and mean (MCAVm) middle cerebral artery blood flow velocity during mild, moderate and heavy cycling exercise. Dynamic CA and steady-state changes in MCAV in relation to changes in arterial pressure were evaluated using transfer function analysis. Pulse pressure increased by 37% and 57% during moderate and heavy exercise, respectively (P<0.05) and the pulsatility of MCAVincreased markedly. Thus, exercise increased MCAVm and MCAVs (P<0.05), but it tended to decrease MCAVd (P=0.06). However, the normalized low frequency transfer function gain between MAP and MCAVm and between SBP and MCAVs remained unchanged from rest to exercise, while that between DBP and MCAVd increased from rest to heavy exercise (P<0.05). These findings suggest that during exercise CA is challenged by a rapid decrease rather than by a rapid increase in blood pressure. However, dynamic CA remains able to modulate blood flow around the exercise-induced increase in MCAVm, even during high intensity exercise.
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