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Articles in PresS, published online ahead of print February 14, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.01002.2001
Submitted on November 15, 2001
Accepted on February 7, 2002
1 Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
* To whom correspondence should be addressed. E-mail: c.j.zuurbier{at}amc.uva.nl.
This study evaluates the effects of anesthesia and fluid support on hemodynamic parameters of the mechanically ventilated mouse of four different strains. All experiments were performed at a similar surgical level of anesthesia, as indicated by the probing of the pedal withdrawal reflex. Three anesthetic regimens (fentanyl-fluanisone-midazolam (FFM), ketamine-medetomidine-atropine (KMA) and isoflurane (ISO)), four commonly used strains (Swiss, CD-1, BalbC and C57Bl6) and three different fluid support strategies (no fluid, 0.2 ml/10g/h 6% polystarch solution and 0.5 ml/10g/h saline) were studied. Mean arterial pressure (MAP) or heart rate (HR) was similar among the 4 strains of mice, except a trend towards lower heart rates for the BalbC mice. In terms of MAP, KMA is the preferred anesthetic for the Swiss and CD-1 mice, whereas KMA or ISO are recommended for BalbC or C57Bl6 mice. In terms of HR, ISO is the preferred anesthetic for the Swiss, CD-1 and C57Bl6 strains. No differences in HR for the three anesthetics were observed for the BalbC strain. . As compared to giving no fluid, both saline and polystarch administration similarly increased MAP by 7±2, 10±2 and 11±2 mm Hg at t = 1, 2 and 3 h, whereas fluid administration was without effect on HR. Saline supplementation resulted in an increased dry/wet ratio of the heart and both fluid regimens decreased total hemoglobine in the blood from 12.6±0.5 to 10.4±0.5 g%. Saline administration was associated with blood acidosis (pH =7.20±0.03) as compared with the Haes- (pH =7.29±0.02) or no fluid-group (pH =7.34±0.03), whereas pCO2 was around 30 mmHg for all groups. It is concluded that, at similar surgical levels of anesthesia, the preferable type of anesthesia (ISO or KMA, but never FFM) depends on the strain used and whether MAP or HR is the focus of study. Additional fluid support is beneficial in terms of raising arterial blood pressure, although this is at the cost of changes in organ water content and increased anaemia.
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