| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Intensive Care, Erasme University Hospital, Brussels, Belgium; Department of Laboratory of Physiology, Free University of Brussels, Brussels, Belgium
2 Department of Cardiac Surgery, Brugmann Hospital, Brussels, Belgium; Department of Laboratory of Physiology, Free University of Brussels, Brussels, Belgium
3 Department of Anesthesiology, Bordet Institute, Brussels, Belgium; Department of Laboratory of Physiology, Free University of Brussels, Brussels, Belgium
4 Department of Laboratory of Physiology, Free University of Brussels, Brussels, Belgium
* To whom correspondence should be addressed. E-mail: serge.brimioulle{at}ulb.ac.be.
Assessement of right ventricular (RV) contractility from end-systolic pressure-volume relationships (ESPVR) is difficult due to problems in measuring RV instantaneous volume and to effects of changes in RV preload or afterload. We therefore investigated in anesthetized dogs whether RV ESPVR and contractility can be determined without measuring RV volume and without changing RV preload or afterload. The maximal RV pressure of isovolumic beats (Pmax) was predicted from isovolumic portions of RV pressure during ejecting beats, and compared to Pmax measured during the first beat after pulmonary artery clamping. In RV pressure-volume loops obtained from RV pressure and integrated pulmonary arterial flow, end-systolic elastance (Ees) was assessed as the slope of Pmax-derived ESPVR, pulmonary artery effective elastance (Ea) as the slope of end-diastolic to end-systolic relation, and coupling efficiency as the Ees/Ea ratio. Predicted Pmax correlated with observed Pmax (r = 0.98 [[plusn]] 0.02). Dobutamine increased Ees from 1.07 to 2.00 mmHg/ml and Ees/Ea ratio from 1.64 to 2.49, and propranolol decreased Ees/Ea from 1.64 to 0.91 (all P < 0.05). After adrenergic blockade, preload reduction did not affect Ees, whereas hypoxia and arterial constriction markedly increased Ea and somewhat increased Ees due to the Anrep effect. Low preload did not affect and high afterload decreased the Ees/Ea ratio. We conclude that in the right ventricle (1) Pmax can be calculated from normal beats, (2) Pmax can be used to determine ESPVR without change in load, and (3) Pmax-derived ESPVR can be used to assess ventricular contractility and ventricular-arterial coupling efficiency.
This article has been cited by other articles:
|
|
 |
|
  P Steendijk, E Meliga, M Valgimigli, F J Ten Cate, and P W Serruys Acute effects of alcohol septal ablation on systolic and diastolic left ventricular function in patients with hypertrophic obstructive cardiomyopathy Heart, October 1, 2008; 94(10): 1318 - 1322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Overbeek, J-W. Lankhaar, N. Westerhof, A. E. Voskuyl, A. Boonstra, J. G. F. Bronzwaer, K. M. J. Marques, E. F. Smit, B. A. C. Dijkmans, and A. Vonk-Noordegraaf Right ventricular contractility in systemic sclerosis-associated and idiopathic pulmonary arterial hypertension Eur. Respir. J., June 1, 2008; 31(6): 1160 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Haddad, S. A. Hunt, D. N. Rosenthal, and D. J. Murphy Right Ventricular Function in Cardiovascular Disease, Part I: Anatomy, Physiology, Aging, and Functional Assessment of the Right Ventricle Circulation, March 18, 2008; 117(11): 1436 - 1448. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Naeije and S. Huez Right ventricular function in pulmonary hypertension: physiological concepts Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H5 - H9. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Pokreisz, G. Marsboom, and S. Janssens Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H75 - H84. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Kerbaul, S. Brimioulle, B. Rondelet, C. Dewachter, I. Hubloue, and R. Naeije How Prostacyclin Improves Cardiac Output in Right Heart Failure in Conjunction with Pulmonary Hypertension Am. J. Respir. Crit. Care Med., April 15, 2007; 175(8): 846 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Fesler, A. Pagnamenta, B. Rondelet, F. Kerbaul, and R. Naeije Effects of sildenafil on hypoxic pulmonary vascular function in dogs J Appl Physiol, October 1, 2006; 101(4): 1085 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G B Bleeker, P Steendijk, E R Holman, C-M Yu, O A Breithardt, T A M Kaandorp, M J Schalij, E E van der Wall, P Nihoyannopoulos, and J J Bax Assessing right ventricular function: the role of echocardiography and complementary technologies Heart, April 1, 2006; 92(suppl_1): i19 - i26. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rondelet, F. Kerbaul, R. Van Beneden, I. Hubloue, S. Huez, P. Fesler, M. Remmelink, S. Brimioulle, I. Salmon, and R. Naeije Prevention of pulmonary vascular remodeling and of decreased BMPR-2 expression by losartan therapy in shunt-induced pulmonary hypertension Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2319 - H2324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Huez, K. Retailleau, P. Unger, A. Pavelescu, J.-L. Vachiery, G. Derumeaux, and R. Naeije Right and left ventricular adaptation to hypoxia: a tissue Doppler imaging study Am J Physiol Heart Circ Physiol, October 1, 2005; 289(4): H1391 - H1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kuehne, S. Yilmaz, P. Steendijk, P. Moore, M. Groenink, M. Saaed, O. Weber, C. B. Higgins, P. Ewert, E. Fleck, et al. Magnetic Resonance Imaging Analysis of Right Ventricular Pressure-Volume Loops: In Vivo Validation and Clinical Application in Patients With Pulmonary Hypertension Circulation, October 5, 2004; 110(14): 2010 - 2016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Wauthy, A. Pagnamenta, F. Vassalli, R. Naeije, and S. Brimioulle Right ventricular adaptation to pulmonary hypertension: an interspecies comparison Am J Physiol Heart Circ Physiol, April 1, 2004; 286(4): H1441 - H1447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Wauthy, S. Abdel Kafi, W. J. Mooi, R. Naeije, and S. Brimioulle Inhaled nitric oxide versus prostacyclin in chronic shunt-induced pulmonary hypertension J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1434 - 1441. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
