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Am J Physiol Heart Circ Physiol (March 7, 2002). doi:10.1152/ajpheart.01024.2001
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Articles in PresS, published online ahead of print March 7, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.01024.2001
Submitted on November 27, 2001
Accepted on February 27, 2002

Nutritive blood flow improves interstitial glucose and lactate exchange in perfused rat hindlimb

John M. B. Newman1*, Stephen Rattigan1, and Michael G Clark1

1 Biochemistry, University of Tasmania, Hobart, Tasmania, Australia

* To whom correspondence should be addressed. E-mail: j.newman{at}utas.edu.au.

Microdialysis was used to assess the interstitial concentrations of glucose and lactate in the constant flow perfused rat hindlimb under varying levels of nutritive flow controlled by vasoconstrictors. Increased nutritive flow was achieved by norepinephrine (NE) or angiotensin II (AII) while decreased nutritive flow by serotonin (5-HT). NE and AII increased oxygen and glucose uptake as well as hindlimb lactate release by 50%. 5-HT decreased oxygen uptake by 15%, but had no significant effect on glucose uptake or hindlimb lactate release. Microdialysis recovery of glucose and lactate were significantly elevated by NE and AII and decreased by 5-HT. The calculated interstitial concentration of glucose was increased by NE and AII, but decreased by 5-HT. The interstitial concentration of lactate was decreased by NE and AII, but increased by 5-HT. In all cases, nitroprusside (NP) reversed the effects of the vasoconstrictors. These data indicate that increased nutritive blood flow enhances the exchange of glucose and lactate by improving the supply of glucose to and the removal of lactate from the interstitium.




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