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Am J Physiol Heart Circ Physiol (February 12, 2004). doi:10.1152/ajpheart.01032.2003
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Submitted on October 30, 2003
Accepted on February 9, 2004

Left Atrial Dilatation due to Chronic Mitral Regurgitation Decreases the Spatiotemporal Organization of Atrial Fibrillation in the Left Atrium

Thomas H. Everett, IV1, Sander Verheule1, Emily E. Wilson1, Scott Foreman1, and Jeffrey E. Olgin1*

1 Cardiovascular Research Institute and Division of Cardiology, University of California San Francisco, San Francisco, CA, USA

* To whom correspondence should be addressed. E-mail: olgin{at}medicine.ucsf.edu.

Atrial conduction properties have been shown to differ among animal models of atrial fibrillation (AF) of rapid atrial pacing (RAP), chronic mitral regurgitation (MR), and control. We hypothesized that these conduction differences would continue with the onset of AF, which would affect AF spatiotemporal organization resulting in model-specific characteristics of AF. Using frequency domain analysis of electrograms acquired from high-density optical mapping, AF from the RA and LA in animals with RAP and MR, were compared to controls. At follow-up, the hearts were excised, perfused, and optical action potentials were recorded from a 2 x 2 cm area of the RA and LA free wall using a 16 x 16 photodiode array. AF was induced with extra stimuli, several 2.4-second AF episodes were recorded in each dog, and a fast Fourier-Transform was calculated. The dominant frequency (DF) was determined, and the organization (OI) was calculated as the ratio of the area under the dominant peak and its harmonics to the total area of the spectrum. All possible pairs of electrograms for each episode were cross-correlated. LA AF in the chronic MR model showed an increase in the highest DF, the number of DF domains, and in frequency gradient as compared to AF in control or RAP. In addition, there was a decrease in OI and in the correlation coefficients in the LA of the MR model. These results suggest that the AF substrate in the MR model may be different from that of control or RAP.




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