| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print March 7, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.01040.2001
Submitted on November 30, 2001
Accepted on March 4, 2002
1 Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
2 Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
3 Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, USA
4 Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI, USA; Section of Cardiothoracic Surgery, Children's Hospital of Wisconsin, Milwaukee, WI, USA
5 Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
6 Division of Pediatric Surgery, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Pharmacology & Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
* To whom correspondence should be addressed. E-mail: jbaker{at}mcw.edu.
Isoflurane mimics the cardioprotective effect of acute ischemic preconditioning with an acute memory phase. We determined if isoflurane can induce delayed cardioprotection, the involvement of ATP-sensitive potassium (KATP) channels and cellular location of the channels. New Zealand White rabbits at 7-10 days of age (n=5-16/group) were exposed to 1% isoflurane/100% oxygen for 2 hours. Hearts exposed 2 hours to 100% oxygen served as untreated controls. Twenty-four hours later resistance to myocardial ischemia was determined using an isolated perfused heart model. Isoflurane significantly reduced infarct size/area at risk (mean±SD) by 50% (10±5%) versus untreated controls (20±6%). Isoflurane increased recovery of pre-ischemic left ventricular developed pressure by 28% (69±4%) versus untreated controls (54±6%). The mitochondrial KATP channel blocker 5-HD completely (55±3%) and the sarcolemmal KATP channel blocker HMR partially (62±3%) attenuated the cardioprotective effects of isoflurane. The combination of 5-HD and HMR1098 completely abolished the cardioprotective effect of isoflurane (56±5%). We conclude that both mitochondrial and sarcolemmal KATP channels contribute to isoflurane induced delayed cardioprotection.
This article has been cited by other articles:
|
|
 |
|
  P. S. Pagel Remote Exposure to Xenon Produces Delayed Preconditioning Against Myocardial Infarction In Vivo: Additional Evidence That Noble Gases Are Not Biologically Inert Anesth. Analg., December 1, 2008; 107(6): 1768 - 1771. [Full Text] [PDF]
|
|
|
|
|
|
N. C. Weber, J. Frassdorf, C. Ratajczak, Y. Grueber, W. Schlack, M. W. Hollmann, and B. Preckel Xenon Induces Late Cardiac Preconditioning In Vivo: A Role for Cyclooxygenase 2? Anesth. Analg., December 1, 2008; 107(6): 1807 - 1813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Jiang, Y. Nakae, M. Ljubkovic, W.-M. Kwok, D. F. Stowe, and Z. J. Bosnjak Isoflurane Activates Human Cardiac Mitochondrial Adenosine Triphosphate-Sensitive K+ Channels Reconstituted in Lipid Bilayers Anesth. Analg., October 1, 2007; 105(4): 926 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lucchinetti, J. Aguirre, J. Feng, M. Zhu, M. Suter, D. R. Spahn, L. Harter, and M. Zaugg Molecular Evidence of Late Preconditioning After Sevoflurane Inhalation in Healthy Volunteers Anesth. Analg., September 1, 2007; 105(3): 629 - 640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Fuentes, M. A. Talamini, W. B. Fulton, E. J. Hanly, A. R. Aurora, and A. De Maio General Anesthesia Delays the Inflammatory Response and Increases Survival for Mice with Endotoxic Shock Clin. Vaccine Immunol., February 1, 2006; 13(2): 281 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wakeno-Takahashi, H. Otani, S. Nakao, H. Imamura, and K. Shingu Isoflurane induces second window of preconditioning through upregulation of inducible nitric oxide synthase in rat heart Am J Physiol Heart Circ Physiol, December 1, 2005; 289(6): H2585 - H2591. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shi, W. C. Hutchins, J. Su, D. Siker, N. Hogg, K. A. Pritchard Jr., A. Keszler, J. S. Tweddell, and J. E. Baker Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H175 - H184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. da Silva, E. Lucchinetti, T. Pasch, M. C. Schaub, and M. Zaugg Ischemic but not pharmacological preconditioning elicits a gene expression profile similar to unprotected myocardium Physiol Genomics, December 15, 2004; 20(1): 117 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zaugg, M. C. Schaub, and P. Foex Myocardial injury and its prevention in the perioperative setting Br. J. Anaesth., July 1, 2004; 93(1): 21 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Riess, D. F. Stowe, and D. C. Warltier Cardiac pharmacological preconditioning with volatile anesthetics: from bench to bedside? Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1603 - H1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Nakae, W.-M. Kwok, Z. J. Bosnjak, and M. T. Jiang Isoflurane activates rat mitochondrial ATP-sensitive K+ channels reconstituted in lipid bilayers Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1865 - H1871. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
