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Articles in PresS, published online ahead of print March 28, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.01042.2001
Submitted on November 29, 2001
Accepted on March 22, 2002
1 School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom
* To whom correspondence should be addressed. E-mail: c.h.orchard{at}leeds.ac.uk.
The effects of acidosis on the action potential, resting potential ICa, IK1, IK, ISS and ICl,ir of rat sub-epicardial (epi) and sub-endocardial (endo) ventricular myocytes were investigated using the patch clamp technique. Action potential duration was shorter in epi than in endo cells. Acidosis (extracellular pH decreased from 7.4 to 6.5) depolarised the resting membrane potential and prolonged the time for 50% repolarization of the action potential in epi and endo cells, although the prolongation was larger in endo cells. At control pH, ICa, IK1, and ISS were not significantly different in epi and endo cells, but IK was larger in epi cells. Acidosis did not alter ICa, IK1, or IK, but decreased ISS; this decrease was larger in endo cells. It is suggested that the acidosis-induced decrease in ISS underlies the prolongation of the action potential. ICl,ir at control pH was Cd2+ sensitive but DIDS resistant. Acidosis increased ICl,ir; it is suggested that the acidosis-induced increase in ICl,ir underlies depolarisation of the resting membrane potential.
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