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Am J Physiol Heart Circ Physiol (July 18, 2002). doi:10.1152/ajpheart.01054.2001
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Articles in PresS, published online ahead of print July 18, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.01054.2001
Submitted on December 3, 2001
Accepted on July 12, 2002

Gender differences in cardiac angiotensin-converting-enzyme expression are normalized in androgen-deprived male mice

Judy R. Freshour1, Sharon E. Chase1, and Karen L. Vikstrom1*

1 Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA

* To whom correspondence should be addressed. E-mail: vikstrok{at}upstate.edu.

Gender differences have been described in the response of the cardiovascular system to a number of stimuli including ventricular remodeling in response to pressure overload, but the molecular basis for these differences remains unclear. Since gender differences in cardiac expression of angiotensin-converting enzyme could contribute to differences in myocardial remodeling, we examined myocardial ACE expression in age-matched, male and female mice. Ventricular ACE was more abundant in male mice than female mice, at both mRNA and protein levels. These differences became apparent once the mice reached sexual maturity and became more pronounced with increasing age. The influence of mouse gonadal status on ventricular ACE expression was also examined. Oophorectomy slightly increased ACE levels in female mice while ventricular ACE levels were substantially decreased in androgen-deprived males. The antithetical changes in ventricular ACE abundance seen in agonadal male and female mice suggest that testosterone as well as estrogen may play a role in regulating ACE expression in the heart.




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