| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Anatomy with Radiology, The University of Auckland, Auckland, New Zealand
2 Department of Medicine, The University of Auckland, Auckland, New Zealand
3 Department of Cardiac Radiology, Green Lane Hospital, Auckland, New Zealand
* To whom correspondence should be addressed. E-mail: a.young{at}auckland.ac.nz.
Although age related impairment of diastolic function is well documented, patterns of regional tissue relaxation impairment with age have not been characterized. MRI tissue tagging with a regional 3D analysis was performed in 15 younger (age 19-26 years) and 16 older (age 60-74 years) normal, healthy volunteers. The peak rate of relaxation of circumferential strain (RC) was decreased in the older group (on average, 105±28 %/s older vs. 163±18 %/s younger, mean±SD, p<0.001), to a greater extent in the lateral wall than the septum (p=0.016), and in the apex than the base (p<0.001). Peak rate of relaxation of longitudinal strain (RL) was also reduced with age (94±27 vs. 155±18 %/s, p<0.001), to a greater extent in the apex than the base (p<0.001). Both RC and RL were greater in the apex than the base only in the younger subjects (p<0.001 for each). Peak rate of torsion reversal (RT) was reduced with age (74±16 vs. 91±15 °/s, p=0.006) to a greater extent in the base than the apex (p=0.035). An increase in regional asynchrony in time to RC and time to RL (p<0.001, for each), but not time to RT, occurred with age. Thus, patterns of regional non-uniformity of myocardial relaxation are altered in a consistent fashion with aging.
This article has been cited by other articles:
|
|
 |
|
  T. Helle-Valle, E. W. Remme, E. Lyseggen, E. Pettersen, T. Vartdal, A. Opdahl, H.-J. Smith, N. F. Osman, H. Ihlen, T. Edvardsen, et al. Clinical assessment of left ventricular rotation and strain: a novel approach for quantification of function in infarcted myocardium and its border zones Am J Physiol Heart Circ Physiol, July 1, 2009; 297(1): H257 - H267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A T Burns, I G McDonald, J D Thomas, A MacIsaac, and D Prior Doin' the twist: new tools for an old concept of myocardial function Heart, August 1, 2008; 94(8): 978 - 983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Dorfman, B. D. Rosen, M. A. Perhonen, T. Tillery, R. McColl, R. M. Peshock, and B. D. Levine Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting J Appl Physiol, April 1, 2008; 104(4): 1037 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Tumkosit, C. G. Martin, E. Bayram, T. M. Morgan, K. S. Lane, P. Rerkpattanapipat, C. A. Hamilton, K. M. Link, and W. G. Hundley Left Ventricular Spherical Remodeling and Apical Myocardial Relaxation: Cardiovascular MR Imaging Measurement of Myocardial Segments Radiology, August 1, 2007; 244(2): 411 - 418. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J.W. Gotte, T. Germans, I. K. Russel, J. J.M. Zwanenburg, J. T. Marcus, A. C. van Rossum, and D. J. van Veldhuisen Myocardial Strain and Torsion Quantified by Cardiovascular Magnetic Resonance Tissue Tagging: Studies in Normal and Impaired Left Ventricular Function J. Am. Coll. Cardiol., November 21, 2006; 48(10): 2002 - 2011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lumens, T. Delhaas, T. Arts, B. R. Cowan, and A. A. Young Impaired subendocardial contractile myofiber function in asymptomatic aged humans, as detected using MRI Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1573 - H1579. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R.S. Fernandes, J. F. Polak, T. Edvardsen, B. Carvalho, A. Gomes, D. A. Bluemke, K. Nasir, D. H. O'Leary, and J. A.C. Lima Subclinical Atherosclerosis and Incipient Regional Myocardial Dysfunction in Asymptomatic Individuals: The Multi-Ethnic Study of Atherosclerosis (MESA) J. Am. Coll. Cardiol., June 20, 2006; 47(12): 2420 - 2428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Serri, P. Reant, M. Lafitte, M. Berhouet, V. Le Bouffos, R. Roudaut, and S. Lafitte Global and Regional Myocardial Function Quantification by Two-Dimensional Strain: Application in Hypertrophic Cardiomyopathy J. Am. Coll. Cardiol., March 21, 2006; 47(6): 1175 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Rosen, B. L. Gerber, T. Edvardsen, E. Castillo, L. C. Amado, K. Nasir, D. L. Kraitchman, N. F. Osman, D. A. Bluemke, and J. A. C. Lima Late systolic onset of regional LV relaxation demonstrated in three-dimensional space by MRI tissue tagging Am J Physiol Heart Circ Physiol, October 1, 2004; 287(4): H1740 - H1746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. M. Zwanenburg, M. J. W. Gotte, J. P. A. Kuijer, R. M. Heethaar, A. C. van Rossum, and J. T. Marcus Timing of cardiac contraction in humans mapped by high-temporal-resolution MRI tagging: early onset and late peak of shortening in lateral wall Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1872 - H1880. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
