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1 Department of Anatomy with Radiology, The University of Auckland, Auckland, New Zealand
2 Department of Medicine, The University of Auckland, Auckland, New Zealand
3 Department of Cardiac Radiology, Green Lane Hospital, Auckland, New Zealand
* To whom correspondence should be addressed. E-mail: a.young{at}auckland.ac.nz.
Although age related impairment of diastolic function is well documented, patterns of regional tissue relaxation impairment with age have not been characterized. MRI tissue tagging with a regional 3D analysis was performed in 15 younger (age 19-26 years) and 16 older (age 60-74 years) normal, healthy volunteers. The peak rate of relaxation of circumferential strain (RC) was decreased in the older group (on average, 105±28 %/s older vs. 163±18 %/s younger, mean±SD, p<0.001), to a greater extent in the lateral wall than the septum (p=0.016), and in the apex than the base (p<0.001). Peak rate of relaxation of longitudinal strain (RL) was also reduced with age (94±27 vs. 155±18 %/s, p<0.001), to a greater extent in the apex than the base (p<0.001). Both RC and RL were greater in the apex than the base only in the younger subjects (p<0.001 for each). Peak rate of torsion reversal (RT) was reduced with age (74±16 vs. 91±15 °/s, p=0.006) to a greater extent in the base than the apex (p=0.035). An increase in regional asynchrony in time to RC and time to RL (p<0.001, for each), but not time to RT, occurred with age. Thus, patterns of regional non-uniformity of myocardial relaxation are altered in a consistent fashion with aging.
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