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Articles in PresS, published online ahead of print February 28, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.01080.2001
Submitted on December 10, 2001
Accepted on February 22, 2002
1 Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA
* To whom correspondence should be addressed. E-mail: tsoukias{at}bme.jhu.edu.
Experimental measurements have suggested a consumption rate of nitric oxide by erythrocytes that is orders of magnitude smaller than that of an equivalent concentration of free hemoglobin in solution. This difference has been attributed to external diffusion limitations in the transport of NO from the plasma to the surface of the erythrocyte or to resistance in the transport through the erythrocytic membrane. A detailed mathematical model is developed to quantify the resistance to NO transport around a single erythrocyte and predict the consumption rate in the presence and absence of extracellular hemoglobin. We provide a description for the NO consumption rate as a function of hematocrit, erythrocyte radius, membrane permeability, and extracellular hemoglobin concentration. We predict a first order rate constant for NO consumption in blood between 7.5x102 and 6.5x103 s-1 at 45% hematocrit for membrane permeability values between 0.1 and 40 cm s-1. Our results suggest that the difference in NO uptake by erythrocytes and free hemoglobin is smaller than previously reported and it is hematocrit dependent.
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