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1 Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA
2 Veterans Administration Ann Arbor Healthcare System, Ann Arbor, MI, USA
3 Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery (Vascular), University of Michigan Medical School, Ann Arbor, MI, USA; Department of Surgery, William Beaumont Hospital, Royal Oak, MI, USA
* To whom correspondence should be addressed. E-mail: lgdalecy{at}umich.edu.
Radiotelemetry of mouse blood pressure accurately monitors systolic pressure, diastolic pressure, heart rate and locomotor activity but requires surgical implantation. Noninvasive measurements of indirect systolic blood pressure have long been available for larger rodents and now are being reported more frequently for mice. This study compared mouse systolic arterial blood pressure measurements using implanted radiotelemetry pressure transducer with simultaneous tail-cuff measurements in the same un-anesthetized mice. The pressure range for comparison was extended by inducing experimental hypertension or by observations of circadian elevations between three AM and six AM. Both trained and untrained tail-cuff operators used both instruments. Every effort was made to follow recommended manufacturer's instructions. With the initial flow based tail-cuff instrument we made 671 comparisons (89 sessions) and found the slope of the linear regression to be 0.118, suggesting poor agreement. In an independent assessment, 277 comparisons (35 sessions) of radiotelemetry measurements with the pulse based tail-cuff instrument were made. The slope of the linear regression of the simultaneous measurements of systolic pressures was 0.98 suggesting agreement. Bland-Altman analysis also supported our interpretation of the linear regression. Thus, while reliable systolic pressure measurements are possible with either tail-cuff or radiotelemetry techniques, in our hands some tail-cuff instruments fail to accurately detect elevated blood pressures. These data, however, do not distinguish whether this instrument-specific tail-cuff failure was due to operator or instrument inadequacies. We strongly advise investigators to obtain an independent and simultaneous validation of tail-cuff determinations of mouse blood pressure before making critical genotyping determinations.
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