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Am J Physiol Heart Circ Physiol (December 18, 2003). doi:10.1152/ajpheart.01100.2001
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Submitted on December 14, 2001
Accepted on November 9, 2003

Effects of left ventricular contractility and coronary vascular resistance on coronary Dynamics

YI-HUI SUN1, TODD J. ANDERSON1, KIM H. PARKER2, and JOHN V. TYBERG1*

1 Department of Medicine and Physiology & Biophysics, University of Calgary, Calgary, Alberta, Canada
2 Department of Biological and Medical Systems, Imperial College of Science, Technology and Medicine, London, United Kingdom

* To whom correspondence should be addressed. E-mail: jtyberg{at}ucalgary.ca.

Wave-intensity analysis, which separates upstream from downstream events and defines their interaction, has been used to study the effects of changes in left ventricular (LV) contractility (Emax) and left circumflex coronary resistance (RLCx) on the coronary systolic flow impediment (CSFI). In 10 anesthetized, open-chest dogs, we measured coronary, aortic, and LV pressures and coronary velocity (Flowire) and flow. Emax was increased by paired pacing and RLCx was modulated by intracoronary infusions of vasodilators (adenosine, nitroglycerin) and a vasoconstrictor (phenylephrine). When both Emax and RLCx were varied, CSFI and the energy of the backward-going compression wave (IW-) were greatest at the highest levels of Emax and the lowest levels of RLCx. IW- was proportional to the CSFI. We conclude that contractility and coronary resistance change CSFI by modulating the backward-going compression wave.




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