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Articles in PresS, published online ahead of print May 23, 2002
Am J Physiol Heart Circ Physiol, 10.1152/ajpheart.01109.2001
Submitted on December 20, 2001
Accepted on May 14, 2002
1 Division of Cardiology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
2 Division of Cardiology, Department of Medicine, Taichung Veterans General Hospital and Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan
3 Department of Pathology and Laboratory Medicine, UCLA School of Medicine, Los Angeles, CA, USA
* To whom correspondence should be addressed. E-mail: chenp{at}cshs.org.
Repetitive rapid activities are present in the PVs in dogs with pacing-induced sustained AF. The mechanisms are unclear. We induced sustained (>48 hours) AF by rapidly pacing the left atrium (LA) in 6 dogs. High-density computerized mapping was done in the PVs and atria. Results show repetitive focal activations in all dogs and in 12/18 mapped PVs. Activation originated from middle PV and then propagated to the LA and distal PV with conduction blocks. The RA was usually activated by a single large wavefront. The mean AF cycle length in the PVs (left superior, 82±6 ms; left inferior, 83±6 ms; right inferior, 83±4 ms) and LA posterior wall (87±5 ms) were significantly (p<0.05) shorter than those in the LA anterior wall (92±4 ms) and RA (107±5 ms). The PVs in normal dogs did not have focal activations during induced AF. No reentrant wavefronts were demonstrated in the PVs. We conclude that nonreentrant focal activations are present in the pulmonary veins in a canine model of pacing-induced sustained AF.
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