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1 Department of Cardiology, Erasme Hospital, Brussels, Belgium
2 Department of Physiology, Erasme Hospital, Brussels, Belgium
3 Division of Cardiovascular Diseases and Division of Hypertension, Mayo Clinic, Rochester, Minnesota, USA
* To whom correspondence should be addressed. E-mail: pvandebo{at}ulb.ac.be.
Background: Beta-adrenergic agonists may increase chemosensitivity in humans. We tested the hypothesis that the beta-1 agonist dobutamine increases peripheral chemosensitivity, in a double-blind placebo controlled randomized and cross-over study. Methods: In 15 healthy subjects, we examined the effects of dobutamine on breathing, hemodynamics and sympathetic nerve activity (SNA, measured using microneurography) during normoxia, isocapnic hypoxia (10% O2), post-hypoxic maximal voluntary end-expiratory apnea, hyperoxic hypercapnia, and cold pressor test (CPT). Results: Dobutamine increased ventilation (7.5+/-0.3 vs. 6.7+/-0.2 L/min, p=0.0004) during normoxia, markedly enhanced the ventilatory (16.1+/-1.6 vs. 11.4+/-0.7 L/min, p<0.0001) and sympathetic (+403+/-94 vs. +222+/-5 %, p<0.03) responses at the 5th minute of isocapnic hypoxia and enhanced the sympathetic response to the apnea performed after hypoxia (+501+/-107 % vs. +291+/-38 % p<0.05). No differences were observed between dobutamine and placebo on the responses to hyperoxic hypercapnia and the CPT. Conclusions: Dobutamine increases ventilation during normoxia and potentiates the ventilatory and sympathetic responses to hypoxia in healthy subjects. Dobutamine does not affect the responses to hyperoxic hypercapnia and the CPT. We conclude that dobutamine enhances peripheral chemosensitivity.
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