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1 Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
* To whom correspondence should be addressed. E-mail: marrob{at}dedalus.lcc.ufmg.br.
The systemic and regional hemodynamics effects of Ang-(1-7) were examined in urethane-anesthetized rats. The blood flow distribution (kidneys, skin, mesentery, lungs, spleen, brain, muscle and adrenals), cardiac output and total peripheral resistance were investigated using fluorescent microspheres. Blood pressure and heart rate were recorded from the brachial artery. Ang-(1-7) infusion (110 fmol/min/10 min, i.v.) significantly increased blood flow (ml/min/g) to the kidney (5.10 ± 1.07 to 8.30 ± 0.97), mesentery (0.73 ± 0.16 to 1.17 ± 0.49), brain (1.32 ± 0.44 to 2.18 ± 0.85) and skin (0.07 ± 0.02 to 0.18 ± 0.07) and the vascular conductance in these organs. Ang-(1-7) also produced a significant increase in cardiac index (30%) and a decrease in total peripheral resistance (2.90 ± 0.55 to 2.15 ± 0.28 mmHg/ml/min/100g). Blood flow to spleen, muscle, lungs and adrenals as well as the blood pressure and heart rate were not altered by the Angiotensin-(1-7) infusion. The selective Ang-(1-7) antagonist, A-779, reduced the blood flow in renal, cerebral, mesenteric and cutaneous beds and blocked the Ang-(1-7)-induced vasodilatation in kidney, mesentery and skin, suggesting a significant role of endogenous Ang-(1-7) in these territories. The effects of Ang-(1-7) on the cerebral blood flow, cardiac index, systolic volume and total peripheral resistance were partially attenuated by A-779. A high dose of Ang-(1-7) (11 pmol/min/10min) caused an opposite effect of that produced by the low dose. Our results show for the first time that Ang-(1-7) has a previously unsuspected potent effect in the blood flow distribution and systemic hemodynamics.
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