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1 Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia, United States
2 Cardiovascular Genetics Division, University of Utah, Salt Lake City, Utah, United States
3 Division of Biostatistics, Washington University, St. Louis, Missouri, United States
4 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States
5 Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, United States
6 Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia, United States; Clinical Research Center, Morehouse School of Medicine, Atlanta, Georgia, United States
* To whom correspondence should be addressed. E-mail: qsong{at}msm.edu.
Objective: Recent epidemiological studies indicated that baseline C-reactive protein (CRP) levels may have value in prediction of cardiovascular risk. Methods and results: Using 6 TagSNPs selected from our complete list of single nucleotide polymorphisms (SNP) on the CRP gene, we investigated the association of CRP genotypes with plasma CRP levels and cardiovascular risk in the NHLBI Family Heart Study (FHS) cohort (1296 Caucasians, male 48.5%, age 54.7±12.8 years). There was a significant trend towards association of CRP haplotypes with CRP levels (p=0.045). Single-SNP analysis indicated a highly significant association of SNP-757 (rs3093059, p=0.0004) and SNP-286 (rs3091244, p=0.0065) and a borderline association of SNP-7180 (rs1341665, p=0.06) with CRP levels. Neither CRP haplotypes nor individual SNP genotypes were associated with IMT of the common carotid arteries, internal carotid arteries, or at the bifurcations of the carotid arteries. Conclusion: These results indicated a strong impact of local SNPs of the CRP gene on plasma CRP levels, but there was no direct evidence that these genetically-controlled CRP elevations by local CRP SNPs contributed to cardiovascular disease phenotypes.
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