AJP - Heart Calcium Transients and Cell-Sarcomere
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Heart Circ Physiol (January 13, 2006). doi:10.1152/ajpheart.01219.2005
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
290/6/H2204    most recent
01219.2005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wang, M.
Right arrow Articles by Meldrum, D. R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, M.
Right arrow Articles by Meldrum, D. R
Submitted on November 17, 2005
Accepted on January 13, 2006

ESTROGEN RECEPTOR ALPHA MEDIATES ACUTE MYOCARDIAL PROTECTION IN FEMALES

Meijing Wang1, Paul Crisostomo1, George M Wairiuko1, and Daniel R Meldrum1*

1 Cellular and Integrative Physiology and Surgery, Indiana University, Indianapolis, IN, USA

* To whom correspondence should be addressed. E-mail: dmeldrum{at}iupui.edu.

Background. Sex differences in myocardial recovery have been reported following acute ischemia and reperfusion injury. Estrogen and the estrogen receptors are critical determinants of cardiovascular gender differences. However, the mechanistic pathways responsible for these differences remain unknown. We hypothesized that estrogen receptor alpha is an important modulator of: 1) myocardial functional recovery following ischemia; and 2) inflammatory signaling via mitogen activated protein kinases (MAPK). Study Design. Adult male and female wildtype (WT) and estrogen receptor alpha knockout (ER1KO) mouse hearts were isolated, perfused via Langendorff model, and subjected to 20 minutes ischemia, 60 minutes reperfusion. Myocardial contractile function (LVDP, +dP/dT, -dP/dT) was continuously recorded. After ischemia/reperfusion, hearts were assessed for expression of inflammatory cytokines (ELISA), and activation of mitogen activated protein kinases and caspase-3 (Western blot). Data were analyzed with two-way ANOVA with the student t test. Results. ER1KO females exhibited significantly less functional recovery than WT females and were similar to WT males. Activated ERK was increased in female WT hearts compared to female ER1KO. Activated JNK was decreased in female WT hearts compared to female ER1KO. No significant differences were found between male WT, female WT, male ER1KO, and female ER1KO in activated p38 MAPK, proinflammatory cytokine expression, and pro-apoptotic signaling. Conclusions. Estrogen receptor alpha plays a role in the protection observed in the female heart. Differential activation of MAPK may mediate this protection. Further studies are necessary to delineate these mechanistic pathways.




This article has been cited by other articles:


Home page
 Exp PhysiolHome page
E. Zhan, T. Keimig, J. Xu, E. Peterson, J. Ding, F. Wang, and X.-P. Yang
Dose-dependent cardiac effect of oestrogen replacement in mice post-myocardial infarction
Exp Physiol, August 1, 2008; 93(8): 982 - 993.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Ray, C. M. Herring, T. A. Markel, P. R. Crisostomo, M. Wang, B. Weil, T. Lahm, and D. R. Meldrum
Deleterious effects of endogenous and exogenous testosterone on mesenchymal stem cell VEGF production
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1498 - R1503.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. R. Bell, E. R. Porrello, C. E. Huggins, S. B. Harrap, and L. M. D. Delbridge
The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy
Am J Physiol Heart Circ Physiol, April 1, 2008; 294(4): H1514 - H1522.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Lahm, K. M. Patel, P. R. Crisostomo, T. A. Markel, M. Wang, C. Herring, and D. R. Meldrum
Endogenous estrogen attenuates pulmonary artery vasoreactivity and acute hypoxic pulmonary vasoconstriction: the effects of sex and menstrual cycle
Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E865 - E871.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. Murphy and C. Steenbergen
Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury
Cardiovasc Res, August 1, 2007; 75(3): 478 - 486.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
G. G. Leparc and R. D. Mitra
Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human
Nucleic Acids Res., May 11, 2007; 35(10): 3192 - 3202.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
C. Wang, P. C. Chiari, D. Weihrauch, J. G. Krolikowski, D. C. Warltier, J. R. Kersten, P. F. Pratt Jr, and P. S. Pagel
Gender-specificity of delayed preconditioning by isoflurane in rabbits: potential role of endothelial nitric oxide synthase.
Anesth. Analg., August 1, 2006; 103(2): 274 - 80, table of contents.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1977 by the American Physiological Society.